hereditary spastic paraplegia


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

hereditary spastic paraplegia

Any of a group of inherited diseases of the central nervous system characterized by muscle spasticity, esp. of the lower extremities.
Synonym: Troyer syndrome
See also: paraplegia
References in periodicals archive ?
Hereditary spastic paraplegia (HSP) includes a large and diverse group of genetic disorders whose main feature is progressive spasticity and weakness in the lower limbs, as a result of continuous distal axonopathy caused by defects in the mechanisms that transport proteins and substances along the axons [90, 91].
Fink, "Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms," Acta Neuropathologica, vol.
FSP is also called hereditary spastic paraplegia and StrA1/4mpell-Lorrain syndrome1.
The importance of er in axons is suggested by the fact that mutations of er-shaping proteins result in hereditary spastic paraplegia (hsp), A motor axon degeneration disease.
Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER shape.
Objective: Hereditary spastic paraplegias are a group of rare neurodegenerative diseases due to the degeneration of the long axons of cortical motor neurons.

Full browser ?