hereditary spastic paraplegia


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hereditary spastic paraplegia

Any of a group of inherited diseases of the central nervous system characterized by muscle spasticity, esp. of the lower extremities.
Synonym: Troyer syndrome
See also: paraplegia
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Hereditary spastic paraplegia (HSP) includes a large and diverse group of genetic disorders whose main feature is progressive spasticity and weakness in the lower limbs, as a result of continuous distal axonopathy caused by defects in the mechanisms that transport proteins and substances along the axons [90, 91].
Fink, "Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms," Acta Neuropathologica, vol.
Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases
FSP is also called hereditary spastic paraplegia and StrA1/4mpell-Lorrain syndrome1.
FAMILIAL SPASTIC PARAPLEGIA" (STRAMPELL-LORRAIN SYNDROME)

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