hereditary nonpolyposis colon cancer

hereditary nonpolyposis colon cancer

Lynch I syndrome Oncology A relatively distinct AD form of cancer that may account for 5-10% of all colorectal CA Clinical Family Hx of colorectal CA at relatively young age, primarily of proximal colon, tendency toward multiple primary tumors; HNPCC may be ssociated with extracolonic tumors–eg, of endometrium Diagnosis Amsterdam criteria. See Amsterdam criteria, Colorectal cancerhMSH-2. Cf Familial adenomatous polyposis.
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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.
Other risks include using estrogen alone, diabetes and a strong family history of colon cancer, particularly a type of colon cancer known as hereditary nonpolyposis colon cancer, or HNPCC.
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.
Mutation screening in the hMLH1 gene in Swedish hereditary nonpolyposis colon cancer families.
Hereditary nonpolyposis colon cancer is caused by a defect in certain genes.
If your family has a history of colorectal and related cancers, you may want to consider genetic testing for mutations in two genes strongly associated with hereditary nonpolyposis colon cancer (HNPCC).
Patients who had familial adenomatous polyposis or hereditary nonpolyposis colon cancer, inflammatory bowel diseases, or previous colon surgery were excluded.
As in genetic testing for hereditary nonpolyposis colon cancer (HNPCC), an affected family member should first be tested.
For people who have mutations associated with a condition that we call hereditary nonpolyposis colon cancer, the lifetime risk is about 80 percent.
Because the prevalence of hereditary nonpolyposis colon cancer is approximately 3% and similar in Eastern (Chinese and Japanese) and Western (European and American) patients with CRC, (39-42) it is plausible that sporadic MSI+ CRCs--which are believed to be due to CIMP-related silencing of the mismatch repair gene MLH1--account for the large difference in the proportion of MSI+ CRCs between CRCs in Western and Eastern populations.

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