hereditary diffuse gastric cancer


Also found in: Acronyms.

hereditary diffuse gastric cancer

An autosomal dominant cancer predisposition syndrome (OMIM:137215) with increased susceptibility to diffuse cancer, which begins in the stomach and typically spreads locally to the oesophagus, small intestine and other organs, as well as to adjacent lymph nodes.
 
Molecular pathology
CDH1 mutation causes hereditary diffuse gastric cancer.
References in periodicals archive ?
Pinheiro et al., "Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression," Gastroenterology, vol.
A short guide to hereditary diffuse gastric cancer. Hered Cancer Clin Pract.
Host factors that may confer higher risk for the development of cancer include mutation of the E-cadherin gene (as in the diffuse type), (11) genetic associations with certain ABO blood groups, male gender, and familial cancer syndromes such as hereditary diffuse gastric cancer (HDGC), familial adenomatous polyposis (FAP), Peutz-Jeghers syndrome, and hereditary non-polyposis colorectal cancer (HNPCC), but consideration of these entities is beyond the scope of this discussion.
The rare syndrome, known as Hereditary Diffuse Gastric Cancer Syndrome, also increases their risk of getting colon cancer, and, for Ms.
Eleven of these families were affected by a type of disease called hereditary diffuse gastric cancer (HDGC).

Full browser ?