NASDAQ: PTGX) orphan drug designation for PTG-300, the company's sub-cutaneous injectable hepcidin
mimetic, for the treatment of beta-thalassemia, a rare disease characterized by chronic anemia and iron overload, the company said.
Biopharmaceutical company Protagonist Therapeutics Inc (NASDAQ:PTGX) said on Tuesday that it has received US Food and Drug Administration (FDA) orphan drug designation for sub-cutaneous injectable hepcidin
mimetic PTG-300 for the treatment of beta-thalassemia, a rare disease characterised by chronic anemia and iron overload.
These factors include hepcidin
, interluckins (IL1-6) and tumor necrosis factor (TNF-alpha)17.
Oral iron supplements increase hepcidin
and decrease iron absorption from daily or twice-daily doses in iron-depleted young women.
pylori gastritis that may cause reduced iron absorption is a decrease in gastric juice ascorbic acid concentration, [11,12] increased hepcidin
production from hepatocytes in response to IL-6 production associated with H.
Newer tests such as soluble transferrin receptor (sTfR), sTfR/ log ferritin ratio, hepcidin
, percentage of hypochromic red blood cells (%HRC) and reticulocyte haemoglobin content (CHr) can distinguish ACD from IDA, and can identify combined ACD and IDA.
Aims and Objectives: Our objective was to demonstrate whether curcumin treatment could attenuate the effect of recombinant human EPO on erythropoiesis in EPO-induced polycythemia, and if so, whether this effect is mediated by changing concentrations of iron and its key regulator hormone hepcidin
predicts uremic accelerated atherosclerosis in chronic hemodialysis patients with diabetic nephropathy.
Elevated serum levels of hepcidin
increases the breakdown of iron transporter protein, ultimately inhibiting iron uptake.
, ferroportin-1 and transferrin are associated with iron metabolism and their expression can be affected under different physiological or pathological conditions.
Objective: To determine the role of hepcidin
hormone levels in iron accumulation in patients with thalassemia major (TM) and thalassemia intermedia (T1).
Keywords: IDA, CKD, ACD, hepcidin
, iron overload, anemia of chronic disease, nutritional anemias, micronutrients.