Incubation of hepatocytes with quercetin and gallic acid increased cell viability as well as altered biochemical parameters induced by hepatotoxin
Also the table revealed that rats treated with the hepatotoxin
developed significant liver damage as observed from reduced levels of hepatospecific enzymes, ALP and SDH, in liver tissues.
2001) used the human liver HepG2 cell line to investigate gene expression changes of two hepatotoxins
In particular, she was using, or had used, medications that are known or potential hepatotoxins
The ability of a hepatoprotective drug to reduce the injurious effects or to preserve the normal hepatic physiological mechanisms, which have been disturbed by a hepatotoxin
, is the index of its protective effects.
D-GalN is a well established hepatotoxin
which induces a diffuse type of liver injury in rats, closely resembling human viral hepatitis (Decker and Keppler, 1972, 1974).
AF', Std and Silymarin (fed at 24 h interval for 13 days and, 2 h before and 6 h after hepatotoxin
on day 14th) on chemically (GalN 300 mg/kg, subcutaneously, prophylactic study) induced stress hepatic function in rats (a) Dose Serum parameters Treatment mg/kg, p.
galactosamine (GalN) has been suggested to activate rat liver macrophages (Kupffer cell) and form free radicals, which might be important in the liver toxicity (Shiratori et al.
As part of a series of studies conducted by the International Life Sciences Institute Health and Environmental Science Institute Technical Committee on the Application of Genomics to Mechanism-Based Risk Assessment, the biological response in rats to the hepatotoxin
clofibrate was investigated.
MP is a known hepatotoxin
that causes periportal cell necrosis and carcinomas in rats (Cunningham et al.
The protective effect of ENN against hepatotoxin
AFB1 was also tested.
It is now known to be one of the most potent hepatotoxins