hepatotoxicity


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hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē),
The capacity of a drug, chemical, or other exposure to produce injury to the liver. Agents with recognized hepatotoxicity include carbon tetrachloride, alcohol, dantrolene sodium, valproic acid, and isonicotinic acid hydrazide.

hepatotoxicity

(hĕp′ə-tō-tŏk-sĭs′ĭ-tē, hĭ-păt′ō-)
n.
1. The quality or condition of being toxic or destructive to the liver.
2. The capacity of a substance to have damaging effects on the liver.

hep′a·to·tox′ic (-tŏk′sĭk) adj.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)
The capacity of a drug, chemical, or other exposure to produce injury to the liver.

hepatotoxicity

The state of being poisonous (toxic) to the liver, or the degree to which a substance is toxic to the liver.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)
Capacity of a drug, chemical, or other exposure to injure the liver.
References in periodicals archive ?
In 2006, Mansour et al investigated the effect of cisplatin treatment on various parameters of hepatotoxicity in rats.
This is likely complicated by delirium due to hepatotoxicity. Further discussion between Ms.
Thus all the above findings suggested that the hepatotoxicity induced by CBZ was noticeably reduced by concurrent administration of propranolol.
Treatment of LTBI is an essential component of the TB elimination strategy.[14] The traditional regimen comprises a 9-month-long treatment with isoniazid.[15] Hepatotoxicity and decreased compliance are major concerns with the daily use of isoniazid for 9 months.
A study found that NC, with accumulation in the hepatocyte membrane, protected hepatotoxicity induced by monocrotaline (23).
It can be concluded preventing of the depletion of GSH reservoirs might be another possible mechanism by which taurine exerts protective effects in PZA-induced hepatotoxicity which is in accordance with other findings.
Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry.
They found that the incidence rate of hepatotoxicity associated with hospital admission was in the range of 3.1-23.4/100000 patient-years.
Lee, "Drug-induced hepatotoxicity," The New England Journal of Medicine, vol.
Interestingly, cases 3 and 4 developed severe hepatotoxicity after switching from Nevirapine to Efavirenz.
The recurrence of elevated transaminases one week post discharge is attributed to rifampin hepatotoxicity. Studies looking at patients taking prophylactic rifampin monotherapy report hepatotoxicity in about 1-2% [30, 31].
Out of that, 34 HIV-infected individuals with hepatotoxicity (grade III/IV) under NNRTI-containing ART regimen, 128 without hepatotoxicity-confirmed liver function test (LFT), and age-matched 152 healthy individuals were consecutively recruited from outpatient clinics of National AIDS Research Institute, Pune.