hepatotoxicity


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hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē),
The capacity of a drug, chemical, or other exposure to produce injury to the liver. Agents with recognized hepatotoxicity include carbon tetrachloride, alcohol, dantrolene sodium, valproic acid, and isonicotinic acid hydrazide.

hepatotoxicity

(hĕp′ə-tō-tŏk-sĭs′ĭ-tē, hĭ-păt′ō-)
n.
1. The quality or condition of being toxic or destructive to the liver.
2. The capacity of a substance to have damaging effects on the liver.

hep′a·to·tox′ic (-tŏk′sĭk) adj.

hepatotoxicity

[hep′ətōtoksis′itē]
Etymology: Gk, hēpar + toxikon, poison
the tendency of an agent, usually a drug or alcohol, to have a destructive effect on the liver.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)
The capacity of a drug, chemical, or other exposure to produce injury to the liver.

hepatotoxicity

The state of being poisonous (toxic) to the liver, or the degree to which a substance is toxic to the liver.

hepatotoxicity (hepˑ··tō·tkˈ·si·sit·ē),

n liver toxicity.

hep·a·to·tox·ic·i·ty

(hep'ă-tō-tok-sis'i-tē)
Capacity of a drug, chemical, or other exposure to injure the liver.
References in periodicals archive ?
The pooled data of 21 studies showed hepatotoxicity on low dose of MTX is the second common cause (18.
The exact mechanism of hepatotoxicity of statins remains unclear (Hwang et al.
KEY WORDS: Complication, Cytomegalovirus, Hepatotoxicity, Mycophenolatemofetil, Kidney transplantation.
There is no evidence regarding the reversibility of hepatotoxicity, in literature, after withholding nickel sulphate.
HCV positive HIV patients, whose baseline ALT levels were in the moderate-to-severe hepatotoxicity (Grade 2 and 3), reduced to 7 from 10 patients, which is about 30% reduction.
Clinical syndromes and consequences of antiretroviral-related hepatotoxicity.
24 It is also suggested that acetaminophen is responsible for hepatotoxicity in the current experiment by increasing oxidative stress in animals of group B and protection was provided by MEPP since the extract contained strong antioxidants and polyphenols such as condensed tannins and proanthocyanidins, anthocyanins (delphinidin, cyanidin and pelargonidin 3-glucosides and 3, 5-diglucosides) and flavinoids.
Acetaminophen (APAP), a widely used antipyretic and analgesic drug, can cause severe and fatal hepatotoxicity when an overdose is taken (Larson et al.
Carvedilol-induced hepatotoxicity is extremely rare.
Hepatotoxicity associated with glucosamine and chondroitin sulfate in patients with chronic liver disease.
The relatively predictable course of intrinsic drug injury contrasts dramatically with idiosyncratic DILI, which is characterized by hepatotoxicity that occurs in a very low percentage of individuals who are exposed to a drug at the same dose for the same duration.