This finding is of particular relevance, since orally ingested N-oxides of PAs have similar hepatotoxic
properties as their parent alkaloids, following their reduction to the corresponding free base in the human intestine (Wiedenfeld 2011; Mattocks 1986).
Patients on potentially hepatotoxic
medications should be counseled to recognize and report symptoms of liver dysfunction, including nausea, vomiting, jaundice, and lower-extremity edema.
Silymarin, the active principle of the milk thistle Silybum marianum, protects experimental animals against various hepatotoxic
21] Risk factors associated with severe ART-related hepatotoxicity were a baseline elevation in serum aminotransferases, concomitant hepatotoxic
medication, thrombocytopenia, renal insufficiency, chronic HBV or HVC co-infection and female gender.
Wg toxicity is attributed to the presence of a hepatotoxic
terpenoid called atractyloside, a powerful inhibitor of cellular respiration and ATP synthesis (7).
The injection is a generic equivalent of Cumberland Pharmaceuticals' Acetadote injection and is used as an antidote to prevent or lessen hepatic injury that occurs following the ingestion of a potentially hepatotoxic
quantity of acetaminophen.
Fluconazole, used for outpatient treatment of cryptococcal meningitis, is potentially hepatotoxic
Reduction in the level of glutathione, an endogenous antioxidant enzyme, favours the hepatotoxic
effect of cigarette smoking [20, 21].
We decided to perform talc pleurodesis by MT with local anesthesia in order to avoid potential hepatotoxic
effects caused by drugs used in general anesthesia.
Background: Alcohol is a known hepatotoxic
agent and cause different varieties of liver damages.
This low kava dose was chosen based on the manufacturer's daily dose recommendation as well as a desire to avoid potential hepatotoxic
effects in participants.
The authors report that hepatitis B virus (HBV) infection, use of hepatotoxic
medicines, and microcystin exposure were associated with liver damage among the children in the study.