ALF is due to massive and rapid hepatocyte
inflammation, resulting from excessive immune attack.
count (cell/reticule)###21.70+- 1.13###14.30+- 0.91*###16.70+-1.01**
Immunohistochemistry showed that 4-HNE was more strongly expressed in the cytoplasm of hepatocytes
in the cyclohexanone-exposed group than in control group in both sexes.
To directly detect albumin secreted by hepatocyte
culture, 3D scaffold-based immunoassay chips have been developed recently (Yan et al., 2015).
With HepatoMune, the micropatterned primary hepatocytes
and fibroblasts are supplemented with primary Kupffer cells, creating highly functional human liver tissue that models inflammation-mediated hepatotoxicity.
In rats, Fabien Caille and colleagues describe the labelling of metoclopramide and show that its transporter-mediated plasma clearance into hepatocytes
is saturable and not modified by the P-glycoprotein inhibitor tariquidar.
transplantation is performed with the purpose of repopulating or replacing only a small portion of the total liver mass.
Gene expression of hepatocyte-specific proteins (protein phosphatase 1 (PP1), human hepatocyte
nuclear factor 4 (HNF4a), albumin (ALB), alpha-fetoprotein (AFP), alpha-1 antitrypsin (A1AT)) was validated using qPCR.
We counted the [BrdU.sup.+] hepatocyte/total hepatocyte
ratios at different time points in each group (Figure 4(c)).
Cho, "Alginate microcapsules prepared with xyloglucan as a synthetic extracellular matrix for hepatocyte
attachment," Biomaterials, vol.
culture systems with reintroduction of physiological levels of shear have been demonstrated to maintain expression of CYP2B6 [5,28].
The former refers to these factors mitogenic in both primary-cultured hepatocytes
and in animal experiments, including hepatocyte
growth factor (HGF), transforming growth factor- (TGF-) [alpha], epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and their common receptor EGFR.