hepatocholangiocarcinoma

cholangiohepatoma

 [ko-lan″je-o-hep″ah-to´mah]
primary carcinoma of the liver of mixed liver cell and bile duct cell origin.
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It has been reported that some liver tumors, including HCC, cholangiocarcinoma, and hepatocholangiocarcinoma, may undergo sarcomatous change [3], a phenomenon closely associated with epithelial-mesenchymal transition (EMT) and neoplastic progression [4, 5].
ICD-Oncology code C22.0 was used to identify patients with PHN that included the following diagnostic groups: hepatocellular cancer, hepatic cell carcinoma, mixed hepatocellular carcinoma, fibrolamellar carcinoma, hepatocholangiolitic carcinoma, mixed bile duct with hepatocellular carcinoma, cholangiocarcinoma with hepatocellular carcinoma, cholangiohepatoma, hepatocarcinoma, hepatocholangiocarcinoma, and malignant embryonal hepatoma.
In one poorly differentiated case, reported as possible hepatocholangiocarcinoma, Hep Par-1 and CK7 was positive in the tumor cells, and polyclonal carcinoembryonic antigen (pCEA) and CK20 were negative.
Although these represent very few cases, this suggests either a resistance to ablation or a tendency for rapid regrowth following ablation for combined hepatocholangiocarcinomas. One published case report describes rapid progression of a confirmed hepatocholangiocarcinoma after ablation.
When Yiamouyiannis analyzed the same data, he found mice with a particularly rare form of liver cancer, known as hepatocholangiocarcinoma. This cancer is so rare, according to Yiamouyiannis, that the odds of its appearance in this study by chance are 1 in 2 million in male mice and 1 in 100,000 in female mice.
This conclusion was based on increases in male and female rats of hepatocellular carcinoma and hepatocholangiocarcinoma, neuroendocrine tumors of the glandular stomach, and the observation of other tumor types in several other tissues, and the primary tumors observed in B6C3[F.sub.1] mice were hepatocellular carcinoma in male and female mice and increased neuroendocrine tumors of the glandular stomach in male mice.
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