hepatitis E

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Related to hepatitis E: hepatitis G, Hepatitis F

Hepatitis E



The hepatitis E virus (HEV) is a common cause of hepatitis that is transmitted via the intestinal tract, and is not caused by the hepatitis A virus. Spread most often by contaminated drinking water, HEV infection occurs mainly in developing countries.


Hepatitis E is also known as epidemic non-A, non-B hepatitis. Like hepatitis A, it is an acute and short-lived illness that can sometimes cause liver failure. HEV, discovered in 1987, is spread by the fecal-oral route. It is constantly present (endemic) in countries where human waste is allowed to get into drinking water without first being purified. Large outbreaks (epidemics) have occurred in Asian and South American countries where there is poor sanitation. In the United States and Canada no outbreaks have been reported, but persons traveling to an endemic region may return with HEV.

Causes and symptoms

There are at least two strains of HEV, one found in Asia and another in Mexico. The virus may start dividing in the gastrointestinal tract, but it grows mostly in the liver. After an incubation period (the time from when a person is first infected by a virus until the appearance of the earliest symptoms) of two to eight weeks, infected persons develop fever, may feel nauseous, lose their appetite, and often have discomfort or actual pain in the right upper part of the abdomen where the liver is located. Some develop yellowing of the skin and the whites of the eyes (jaundice). Most often the illness is mild and disappears within a few weeks with no lasting effects. Children younger than 14 years and persons over age 50 seldom have jaundice or show other clinical signs of hepatitis.
Hepatitis E never becomes a chronic (long-lasting) illness, but on rare occasions the acute illness damages and destroys so many liver cells that the liver can no longer function. This is called fulminant liver failure, and may cause death. Pregnant women are at much higher risk of dying from fulminant liver failure; this increased risk is not true of any other type of viral hepatitis. The great majority of patients who recover from acute infection do not continue to carry HEV and cannot pass on the infection to others.


HEV can be found by microscopically examining a stool sample, but this is not a reliable test, as the virus often dies when stored for a short time. Like other hepatitis viruses, HEV stimulates the body's immune system to produce a substance called an antibody, which can swallow up and destroy the virus. Blood tests can determine elevated antibody levels, which indicate the presence of HEV virus in the body. Unfortunately, such antibody blood tests are not widely available.


There is no way of effectively treating the symptoms of any acute hepatitis, including hepatitis E. During acute infection, a patient should take a balanced diet and rest in bed as needed.


In the United States hepatitis E is not a fatal illness, but elsewhere about 1-2% of those infected die of advanced liver failure. In pregnant women the death rate is as high as 20%. It is not clear whether having hepatitis E once guarantees against future HEV infection.


Most attempts to use blood serum containing HEV antibody to prevent hepatitis in those exposed to HEV have failed. Hopefully, this approach can be made to work so that pregnant women living in endemic areas can be protected. No vaccine is available, though several are being tested. It also is possible that effective anti-viral drugs will be found. The best ways to prevent hepatitis E are to provide safe drinking water and take precautions to use sterilized water and beverages when traveling.

Key terms

Antibody — A substance made by the body's immune system in response to an invading virus, the antibodies then attack and destroy the virus.
Incubation period — The time from when a person is first infected by a virus until the appearance of the earliest symptoms.
Jaundice — Yellowing of the skin that occurs when pigments normally eliminated by the liver collect in high amounts in the blood.
Sanitation — The process of keeping drinking water, foods, or any anything else with which people come into contact free of microorganisms such as viruses.
Vaccine — A substance prepared from a weakened or killed virus which, when injected, stimulates the immune system to produce antibodies that can prevent infection by the natural virus.



American Liver Foundation. 1425 Pompton Ave., Cedar Grove, NJ 07009. (800) 223-0179. http://www.liverfoundation.org.


King, J. W. Bug Bytes. Louisiana State University Medical Center. 〈http://www.ccm.lsumc.edu/bugbytes〉.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

vi·ral hep·a·ti·tis type E

hepatitis caused by a nonenveloped, single-stranded, positive-sense RNA virus 27-34 nm in diameter, unrelated to other hepatitis and belonging to the family Caliciviridae; it is the principal cause of enterically transmitted, waterborne, epidemic NANB hepatitis occurring primarily in Asia, Africa, and South America.
Synonym(s): hepatitis E
Farlex Partner Medical Dictionary © Farlex 2012

hepatitis E

An acute viral hepatitis caused by an RNA virus that is transmitted by ingesting contaminated food and water. It is endemic in developing countries and has occurred in epidemics in regions of Asia, Africa, and Central America.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

hepatitis E

A hepatitis caused by a single-stranded RNA virus; it has been implicated in major epidemics where sanitation is poor, drinking water contaminated, and population malnourished
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

hep·a·ti·tis E

A viral hepatitis occurring chiefly in the tropics; transmitted by the fecal-oral route, it does not become chronic or lead to a carrier state, but has a higher mortality than hepatitis A, particularly in pregnancy.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

hepatitis E

A liver inflammation caused by a single-strand, non-enveloped RNA virus 27–34 nm in diameter, known as hepatitis virus E (HEV), that is spread, waterborne, by the faecal-oral route. The first outbreak in Delhi, spread by sewage and flooding, caused 30,000 cases of jaundice. By early 2005 the disease was endemic or epidemic throughout the whole of north Africa, the middle East, south Asia and China, parts of south-east Asia and central America. There is a mortality of up to 4 per cent, but in pregnant women the mortality may be as high as 20 per cent.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United States.
Consumption of wild boar linked to cases of hepatitis E. J Hepatol.
Acute hepatitis E of a man who consumed wild boar meat prior to the onset of illness in Nagasaki, Japan.
Prevalence of hepatitis E virus (HEV) infection in wild boars and deer and genetic identification of a genotype 3 HEV from a boar in Japan.
The mean number of hepatitis E serologic tests performed at the Victorian Infectious Diseases Reference Laboratory per quarter over the previous 5 years was 51.6 (Figure 2).
Overseas hepatitis E activity does appear to have increased during this period.
The first confirmed outbreak of hepatitis E with [approximately equal to]29,000 cases of hepatitis occurred in Delhi in 1955-1956 when raw sewage contaminated drinking water during heavy flooding (2,11,14).
Increased diagnoses of hepatitis E in Victorian travelers may have provided "early warning" of an evolving outbreak in an HEV-endemic area, particularly if a similar increase is reported in other non-HEV-endemic areas.
Clinical and epidemiological implications of swine hepatitis E virus infection.
Analysis of the complete genome sequence of indigenous swine hepatitis E virus isolated in Japan.
Characterization of Japanese swine and human hepatitis E virus isolates with 99% identity over the entire genome.
His current research interests lie in the pathogenesis of porcine multisystemic wasting syndrome and the incidence and prevalence of animal hepatitis E virus in relation to zoonoses.