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This pre-gastric absorption avoids first pass metabolism and can be an immense advantage in drugs that go through a great deal of hepatic metabolism.
Background: Our previous study has shown that Coreopsis tinctoria increases insulin sensitivity and regulates hepatic metabolism in high-fat diet (HFD)-induced insulin resistance rats.
Sublingual route bypasses the first pass hepatic metabolism due to rich blood supply of oral mucosa.
The authors of this report suggested that cirrhosis results in impaired hepatic metabolism of selenomethionine to selenide (one of the biologically active forms of selenium).
Therefore, in the present study we examined whether neonatal MSG treatment later results in hepatic metabolism dysfunction by analysing local carbohydrate and lipid metabolic pathways.
Importance of hepatic metabolism in the antiaggregating activity of the thienopyridine clopidogrel," Biochemical Pharmacology, vol.
Antacids, analgesics, antifungals, anticonvulsants, and antiretrovirals are all known to affect hepatic metabolism and may affect oral contraceptive efficacy.
At the moment, in vitro to in vivo extrapolation of cytochrome P450 mediated hepatic metabolism is well established, whereas bridging pre-clinical data on non-CYP mediated metabolism, extrahepatic metabolism and transporters is more challenging.
Although most BZDs are metabolized hepatically, temazepam is subject to minimal hepatic metabolism.
The technology, in conjunction with human and animal hepatocytes, provides a fully integrated, unique physiologic model that combines uptake and efflux transporters with hepatic metabolism.
Hepatic metabolism of propionate and methylmalonate in growing lambs.
Plasma lipoproteins and regulation of hepatic metabolism of fatty acids in altered thyroid states.
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