hepatic metabolism

hepatic metabolism

Therapeutics The constellation of chemical alterations to drugs or metabolites that occur in the liver, carried out by microsomal enzyme systems, which catalyze glucuronide conjugation, drug oxidation, reduction and hydrolysis. See Metabolism.
References in periodicals archive ?
Under physiological conditions, hepatic metabolism is a major source of ROS production which is balanced by a similar rate of their consumption by various antioxidants in the body.
SAN FRANCISCO -- Patients with chronic liver disease are prescribed opioids and benzodiazepines at very high rates, despite risk for adverse consequences because of hepatic metabolism, according to results from a large longitudinal study of national data.
Advantages of microneedle drug delivery systems include the prevention of gastrointestinal degradation and food-related inconsistency in absorption, avoidance of first pass hepatic metabolism, possibility of improved bioavailability, maintenance of relatively constant plasma concentrations for up to 7 days with the same patch and elimination of pain, discomfort, risk of infection and poor compliance associated with injections.
Transdermal therapy can also be considered for women with metabolic syndrome, hypertriglyceridemia, and fatty liver, since this route avoids first-pass hepatic metabolism.
Altered hepatic metabolism resulting from coadministration with amiodarone and transient renal impairment synergistically resulted in supratherapeutic serum levels of rivaroxaban in our patient resulting in nontraumatic hemopericardium and eventual cardiac tamponade.
Plasma lipoproteins and regulation of hepatic metabolism of fatty acids in altered thyroid states.
They based their hypothesis on the effect of hypoxia, which potentially impairs the hepatic metabolism, including the microsomal function of the liver.
Green, "NASH - Hepatic metabolism and not simply the metabolic syndrome," Hepatology, vol.
UCP2, a mitochondrial anion carrier protein [39], plays a key role as a moderator of ROS production in hepatic metabolism [40,41].
This pre-gastric absorption avoids first pass metabolism and can be an immense advantage in drugs that go through a great deal of hepatic metabolism. Although chewable tablets have been on the market for some time, they are not the same as the new ODTs.
The section ends with a subchapter that outlines the particularities of the hepatic metabolism of psychotropic medication.
Background: Our previous study has shown that Coreopsis tinctoria increases insulin sensitivity and regulates hepatic metabolism in high-fat diet (HFD)-induced insulin resistance rats.