After inducing acute hepatic injury
, levels of liver enzymes and white blood cells were increased markedly.
The liver biopsies of our patients showed inflammatory cell infiltrates that are comprised predominantly of eosinophils and neutrophils with some biopsies showing lymphocyte infiltrates; these findings suggest that hepatic injury
may be immune-mediated in our patients.
Several experimental models of NASH reported high levels of LPS leading to hepatic injury
through the recruitment of inflammatory cells [5, 42].
Considering that the liver is particularly unique in terms of regeneration, further experimental and clinical studies are necessary to clarify the supportive effects of MT and UDCA treatments on the stimulated stem cell activity in hepatic injury
The pattern of liver enzyme levels indicated that ketoconazole, fluconazole, and itraconazole caused mixed hepatic injury
(i.e., cholestatic-hepatocellular injury) while griseofulvin and terbinafine appear to have predominantly resulted in cholestatic injury.
Cholestatic Hepatic Injury
. The hepatic derangement in patients with GD ranges from mild laboratory abnormalities without clinical features to overt hepatitis , with either hepatitic or cholestatic injury .
One study showed that the suppression of p53 leads to a decrease in NAFLD-induced hepatic injury
In previous study , we demonstrated that lemongrass essential oil improves the hepatic injury
caused by APAP, and in this present study the effect of citral, the major component of this oil, was evaluated.
Moritz et al., "Cell-mediated hepatic injury
in alcoholic liver disease," Gastroenterology, vol.
GSH also alleviates the oxidative hepatic injury
induced by dengue virus via inhibiting proinflammatory cytokines .
Systems Biology Investigation to Discover Metabolic Biomarkers of Acetaminophen-Induced Hepatic Injury
Using Integrated Transcriptomics and Metabolomics.
ZINBRYTA prescribing information also includes warnings and precautions for hepatic injury
, immune-mediated disorders, acute hypersensitivity (inflammatory reaction), infections, depression and suicide.