We observed similar changes in our study but hepatic cord pattern was maintained.
Apoptosis was not observed in these groups and the hepatic cord pattern also remained unaffected.
Histology of the normal control group showed central vein surrounded by hepatic cord of cells with clear sinusoidal spaces lined by endothelial cells (Fig.
Liver inflammation is associated with activation of CD68+ macrophages and trigger migration of macrophages into hepatic cords where these macrophages secrete proinflammatory cytokines such as TNF-[alpha] and IL-6 (Kiso et al.
Stelic's Stem Cell Dynamism Research Team has shown that hepatic cord regeneration in acute liver cell damage is regulated at the in vivo level by a protein called chemokine CXCL10.
Immunohistological testing for type IV collagen5 also showed that hepatic cord regeneration was proceeding extremely well.
Inset shows prominent hepatocellular necrosis and dropout, and erythrocytes replace the hepatic cords
(there is some artifactual formalin pigment [acid hematin] in necrotic hepatocytes).
04 ml) the rigorous degenerative alterations in the hepatic cords
and disruption in the sequence of cells around the blood vessels was observed in liver of Larus argentatus.
05 each) On histological examination of group B, the normal hepatic architecture was distorted with loss of classically arranged hepatic cords
24,25 Current findings also corroborate with those of the earlier studies in which necrosis of hepatocytes, pyknotic nuclei and deranged hepatic cords
were reported in fluoride-treated adult rats.
In addition, the livers showed severe edema accompanied by dilation of the space of Disse, bile stasis within canaliculi and hepatocytes, and atrophy of the hepatic cords
Liver tissue samples from the control rats showed normal lobular architecture with central veins, radiating hepatic cords
and little collagen deposition (Fig.