heparin-induced thrombocytopenia


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to heparin-induced thrombocytopenia: thrombin, disseminated intravascular coagulation

heparin-induced thrombocytopenia

Acquired thrombocytopenia affecting some heparin-treated Pts–HTPs, defined as a ↓ platelet count during or shortly after heparin exposure; HIT is a markedly prothrombotic disorder seen in Pts who are at a high baseline risk for venous thrombosis DiffDx Antiphospholipid antibody syndrome, DIC, Trousseau syndrome–migratory thrombophlebitis & malignancy, TTP/HUS, thrombocytopenia and 'showers' of microthrombi Clinical HIT occurs 6-10 days after heparin exposure Diagnosis Aggregation studies using platelets from Pts known to be sensitive to antibody; quantification of serotonin release from platelets radiolabeled with serotonin in assay using Pt serum.

heparin-induced thrombocytopenia

Thrombocytopenia caused by an immune reaction to heparin. It may lead to widespread or potentially life-threatening blood clotting rather than bleeding. See: white-clot syndrome

CAUTION!

Patients whose platelet counts drop significantly during exposure to heparin should discontinue the drug immediately.

heparin-induced thrombocytopenia

A blood platelet deficiency disorder caused by a reaction to heparin. The condition is caused by antibodies, usually of the IgG class against a heparin-platelet factor IV complex on the surface of platelets. Paradoxically, the condition features thrombosis and embolism with the risk of stroke and other serious arterial occlusion effects. This is because the immune complexes formed combine with the antibody Fc receptors of platelets causing their activation and the initiation of clotting.
References in periodicals archive ?
Thomaschewski et al., "The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia," Blood, vol.
Bachelot et al., "Tests for heparin-induced thrombocytopenia in primary antiphospholipid syndrome," British Journal of Haematology, vol.
Lepirudin anticoagulation for heparin-induced thrombocytopenia after cardiac surgery in a pediatric patient.
Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood 2005 Jan;105(1):131-138.
Warkentin TE, Roberts RS, Hirsh J, Kelton JG 2003 An improved definition of immune heparin-induced thrombocytopenia in postoperative orthopedic patients Archives of Internal Medicine 163 2518-2524
2.3% of patients) and significantly less heparin-induced thrombocytopenia (0.3% vs.
Heparin-induced thrombocytopenia. New England Journal of Medicine, 355(8), 809-817.
The use of heparin has risks, including drug interaction, allergic reaction and heparin-induced thrombocytopenia (Cesaro et al, 2009).
Fondaparinux and hirudin need to be considered when heparin-induced thrombocytopenia has been diagnosed.
National survey of heparin-induced thrombocytopenia in the haemodialysis population of the UK population.
Bivalirudin has been more commonly used as a heparin substitute in the setting of APLS and heparin-induced thrombocytopenia with or without thrombosis (5,7).
Heparin, however, is also associated with heparin-induced thrombocytopenia (HIT), a potentially life- and limb-threatening immunological reaction.

Full browser ?