heparin-binding protein

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A gene on chromosome 19q13.3 that encodes an azurophil granule protein of the serine protease family (but is not itself a serine protease), which has monocyte chemotactic and antibacterial activity, and acts as an important multifunctional inflammatory mediator. The genes encoding the AZU1 protein product, neutrophil elastase 2 and proteinase 3, are in a cluster at chromosome 19pter, and all three are expressed and packaged together into azurophil granules during neutrophil differentiation.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

heparin-binding protein

A proinflammatory, antimicrobial peptide released by neutrophils. It increases the permeability of blood vessels. It is found in high concentrations in plasma of patients with septic shock.
See also: protein
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Miller, "Heparin-binding protein (CAP37) is internalized in monocytes and increases LPS-induced monocyte activation," The Journal of Immunology, vol.
Perhaps the most significant discovery has been the participation of heparin-binding proteins (HBPs) in the sperm capacitation (THERIEN et al., 1995).
TABLE 1 Potential Advantages of Low-Molecular-Weight Heparins (LMWHs) Basic science research findings LMWHs bind less to heparin-binding proteins, LMWHs bind less to endothelial cells and matrix proteins.
For example, the bFGF photoaptamer has a [K.sub.d] of -16 pmol/L, a photo cross-linking yield of 50%, and specific binding to bFGF that is more than three orders of magnitude higher than binding to other heparin-binding proteins, such as vascular endothelial growth factor and platelet-derived growth factor (13).

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