heparin-binding epidermal growth factor


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Related to heparin-binding epidermal growth factor: Epidermal growth factor receptor

heparin-binding epidermal growth factor

Abbreviation: HB-EGF
A cytokine monokine involved in immune and inflammatory responses. It is produced by macrophages and stimulates production of smooth muscle cells and fibroblasts.
See also: factor
References in periodicals archive ?
Previous studies have shown the stimulating effect of Helicobacter pylori on the gene expression of heparin-binding epidermal growth factor (HBEGF) using the gastric epithelial cell line KATO-III.
The findings that NEC is associated with reduced intestinal stem cells is supportive of earlier work by Besner and colleagues, who not only showed that the intestinal stem cells and all subsequent lineages were reduced in experimental NEC, but also demonstrated that the administration of the heparin-binding epidermal growth factor (HB-EGF) could restore intestinal stem cells and therefore attenuate the severity of NEC [67].
Signaling proteins such as VEGF, PDGF, basic fibroblast growth factor (bFGF), transforming growth factor, and heparin-binding epidermal growth factor (HB-EGF) appear to play a role in the regeneration of tissue within scaffolds and restoration of specialized function, in part through the regulation of vessel density, size and distribution.

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