Klinger, "The role of heparanase
in diseases of the glomeruli," Archivum Immunologiae et Therapia Experimentalis, vol.
Neurotrophins seem to promote melanoma cell invasion by stimulating and sustaining growth and migration, for example, by inducing the expression of heparanase
or cytoskeletal rearrangements .
Domann, "Overexpression of extracellular superoxide dismutase attenuates heparanase
expression and inhibits breast carcinoma cell growth and invasion," Cancer Research, vol.
, hyaluronan, and CD44 in cancers: a breast carcinoma perspective," Cancer Research, vol.
PI-88 is a multi-targeted cancer therapeutic in late stage development which inhibits both angiogenesis (or tumour promoting) factors such as Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factors (FGF) 1 and 2, and heparanase
, an enzyme implicated in metastasis.
TF gene (F3) expression can also be regulated in some cancers by heparanase
, a mammalian endo-[beta]-D-glucuronidase cleaving heparan sulfate chains in the extracellular matrix and on cell surfaces (9).
Research teams in Australia and Israel have both found the long-sought gene for heparanase
, an enzyme that cancer cells use to spread through the body.
Likar et al., "Heparanase
cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis," Development, vol.
He et al., "Expression of heparanase
gene, CD44v6, MMP-7 and nm23 protein and their relationship with the invasion and metastasis of gastric carcinomas," World Journal of Gastroenterology, vol.
Based on these observations, it seems that GBM is critical for limited protein leakage as supported by the findings that removal of heparan sulfate by heparanase
infusion or anti-heparan sulfate antibody treatment showed massive proteinuria and high GBM permeability.
(HPSE) is an endo-[beta]-D-glucuronidase that cleaves specific linkages in the structure of the HS, yielding fragments which are able to contain biological activity.
showed reduced proteinuria by 1,25-dihydroxyvitamin D treatment connected to reduced heparanase
expression in podocytes .