GPC3

(redirected from heparan sulphate proteoglycan)

GPC3

A gene on chromosome Xq26.1 that encodes glypican 3, a cell surface proteoglycan with heparan sulfate that inhibits the dipeptidyl peptidase activity of DPP4. It may be involved in modulating growth of mesodermal tissues, in IGF2-receptor interactions, and in cellular growth and tumourigenesis.

Molecular Pathology
Defects in GPC3 cause Simpson-Golabi-Behmel syndrome.
References in periodicals archive ?
Loss of anionic charge in biochemical terms means loss of normal heparan sulphate proteoglycan, the main glycosaminoglycan component of basement membranes of glomeruli.
The multiplicity of the effects of heparan sulphate proteoglycan might well explain the strong association between vascular dysfunction and renal and extrarenal complications.
Isolation and characterisation of putative adhesins from Helicobacter pylori with affinity for heparan sulphate proteoglycan.