Early postoperative stroke was registered in the rest of 5 patients, 3 cases of ischemic and 2 cases of hemorrhagic (one case of hemorrhagic transformation
and one due to cerebrovacular hypeperfusion).
Furthermore, according to the selected lesion type, the radiologist classified other variables: the presence of any imaging contraindication to the t-PA administration (e.g., intraaxial neoplasm, arteriovenous malformation, aneurysm, hemorrhagic transformation
of an ischemic infarct, hypodensity >1/3 of the vascular distribution of the middle cerebral artery); confidence in the presence of the hyperdense middle cerebral artery sign (HMCA); and the ASPECTS score (ranging from 0-10), which is a method for assessing the size of an infarct on CT scans in patients with acute stroke.
Background: Whether there is a relationship between glomerular filtration rate (GFR) and hemorrhagic transformation
(HT) after acute ischemic stroke (AIS) is still under debate.
The risk factors are young age, male sex, cortical involvement, and hemorrhagic transformation
: a review of the rate of haemorrhage in the major clinical trials of acute ischemic stroke.
In contrast, the administration of Edaravone, a free radical scavenger, in patients with cardiogenic embolism increased hemorrhagic transformation
On the other hand, dabigatran did not significantly increase hemorrhagic transformation
after transient focal cerebral ischemia in mice  or risk of secondary hemorrhages after thrombolysis in various rodent models of ischemia and reperfusion  or collagenase-induced intracranial hemorrhage .
The neurological score, infarction volume, hemorrhagic transformation
rate, and blood test data were analyzed using the Steel-Dwass method or Bonferroni-Dunn method as appropriate in multiple comparisons.
We evaluated early neurological deterioration (END), hemorrhagic transformation
, hospitalization duration, discharge NIHSS scores, in-hospital mortality events, and the 3-month modified Rankin scale (mRS) scores.
Although HARM has been shown to be associated with larger DWI lesion volumes, hemorrhagic transformation
, and poor clinical outcome , cases of patients with unremarkable DWI and demonstration of HARM have been reported [16, 17].
(HT) occurs predominantly in acute ischemic stroke (AIS) with cardioembolic origin and could be seen at any time following ischemic attack (I).
However, within three weeks (range: 6 days-3 weeks), the follow-up T2 or [T2.sup.*]-weighted images showed hypointense changes in the same regions (Figure 4(b)), suggestive of hemorrhagic transformation
. The lesions were therefore interpreted as laminar cortical infarcts with hemorrhagic transformation