Postexposure administration of hemopexin
, a heme-scavenging protein, decreased lung injury and improved survival. Studies also demonstrated that humanized transgenic mice overexpressing HO-1 were significantly protected from exposure to Br[sub]2. These are the first studies delineating the pathogenesis of Br[sub]2 toxicity in respiratory diseases and demonstrated the critical role of heme in ARDS caused by Br[sub]2[Figure 3].
Based on a multipe sequence alignment with representative orthologues from other fish species and human hemopexin
, the CcWap65 polypeptide shares varying degrees of homology with their corresponding orthologues (Fig.
(1984) The structure of a trisialyl di-antennary N-type glycopeptide obtained from rat plasma hemopexin
Li et al., "The hemopexin
domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of Schwann cells by binding to low-density lipoprotein receptor-related protein," The Journal of Neuroscience, vol.
Welsh et al., "Hemopexin
induces nephrin-dependent reorganization of the actin cytoskeleton in podocytes," Journal of the American Society of Nephrology, vol.
Proteolytic action of kallikrein-related peptidase 7 produces unique active matrix metalloproteinase-9 lacking the C-terminal hemopexin
Association of Hemopexin
in Tear Film and Conjunctival macrophages With Vernal Keratoconjuctivitis.
These "pawns" include transferrin, lactoferrin, ferritin, haptoglobin (hemoglobin chaperone), and hemopexin
(heme chaperone), all of which are modified in the presence of infection.
Zucker, "Distinct roles for the catalytic and hemopexin
domains of membrane type 1-matrix metalloproteinase in substrate degradation and cell migration," Journal of Biological Chemistry, vol.
plasma concentrations of acute phase proteins or reactants such as haptoglobin (Hp), alpha-acid glycoprotein, alpha-1-antitrypsin, fibrinogen, complement components C3 and C4 and hemopexin
, immunoglobulins, cytokines) and substances which are known to induce an acute phase response (e.g.
Role of the hemopexin
domain of matrix metalloproteinases in cell migration.