hemolytic uremic syndrome


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hemolytic

 [he″mo-lit´ik]
pertaining to, characterized by, or producing hemolysis.
hemolytic anemia anemia caused by the increased destruction of erythrocytes. A frequently fatal type occurs in infants as a result of Rh incompatibility with the mother's blood (see Rh factor and erythroblastosis fetalis). Other types result from mismatched blood transfusions; from industrial poisons such as benzene, trinitrotoluene (TNT), or aniline; and from hypersensitivity to certain antibiotics and tranquilizers (drug-induced hemolytic anemia). Another important cause is mechanical obstruction caused by microvascular or valvular abnormalities. In addition, it sometimes occurs as a result of a disorder of the immune response in which B-cell–produced antibodies fail to recognize the body's own erythrocytes and directly attack and destroy them (autoimmune hemolytic anemia). Finally, some types of hemolytic anemia appear in the course of other diseases such as leukemia, hodgkin's disease, other types of cancer, acute alcoholism, and liver diseases. Along with the usual symptoms of anemia, the patient may exhibit jaundice. If the cause of the condition can be determined, and if it can be successfully treated, there is a good chance of recovery. steroids and transfusion therapy are used to treat some types. In other cases, surgical removal of the spleen may bring about great improvement.
hemolytic disease of newborn erythroblastosis fetalis.
hemolytic jaundice a rare, chronic, and generally hereditary disease characterized by periods of excessive hemolysis due to abnormal fragility of the erythrocytes, which are small and spheroidal. It is accompanied by enlargement of the spleen and by jaundice. The hereditary form is also known as familial acholuric jaundice; there is also a rare acquired form. See also hyperbilirubinemia.
hemolytic uremic syndrome a form of thrombotic microangiopathy with renal failure, hemolytic anemia, and severe thrombocytopenia and purpura, usually seen in children but occurring at any age. Some authorities consider it identical to thrombotic thrombocytopenic purpura.

he·mo·lyt·ic u·re·mic syn·drome

[MIM*235400]
hemolytic anemia and thrombocytopenia occurring with acute renal failure; in children, characterized by sudden onset of gastrointestinal bleeding, hematuria, oliguria, and microangiopathic hemolytic anemia; in adults, associated with complications of pregnancy following normal delivery, or associated with oral contraceptive use or with infection; often caused by infection with Escherichia coli.

hemolytic uremic syndrome

a kidney disorder marked by renal failure, microangiopathic hemolytic anemia, and platelet deficiency. The syndrome, the cause of which is unknown, usually occurs in infancy. With conservative management, including dialysis, most infants and children recover. The prognosis in adults is uncertain.

he·mo·lyt·ic u·re·mic syn·drome

(hē'mō-lit'ik yūr-ē'mik sin'drōm)
Combination of hemolytic anemia and thrombocytopenia that occurs with acute renal failure. In children, characterized by sudden onset of gastrointestinal bleeding, hematuria, oliguria, and microangiopathic hemolytic anemia in association with intestinal infection by Shigella, Salmonella, or Escherichia coli strain O157:H7; in adults, associated with complications of pregnancy following normal delivery, with oral contraceptive use, or with infection.
Synonym(s): haemolytic uremic syndrome.
References in periodicals archive ?
Eculizumab for atypical hemolytic uremic syndrome recurrence in renal transplantation.
A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders.
Central nervous system involvement in hemolytic uremic syndrome (HUS)-a retrospective analysis of cerebral CT and MRI studies.
Complete factor H deficiency-associated atypical hemolytic uremic syndrome in a neonate.
Hemolytic uremic syndrome (HUS) is a disease of rapid onset characterized by microangiopathic hemolytic anemia, acute renal failure, thrombocytopenia, and various degrees of central nervous system complications that can result in chronic, irreversible renal dysfunction or death (Tzipori, Sheoran, Akiyoshi, Donohue-Rolfe, & Trachtman, 2004).
Further evidence associating hemolytic uremic syndrome with infection by verotoxin-producing Escherichia coli O157:H7.
According to medical experts, most infected persons recover in 5 to 10 days, but about 5 percent to 10 percent of infected individuals develop Hemolytic Uremic Syndrome, the most common cause of kidney failure in children.
CHICAGO -- Aggressive fluid management and avoidance of medication are key in preventing the development of hemolytic uremic syndrome in children with Escherichia coli diarrhea, said Dr.
While the clinical diagnosis of hemolytic uremic syndrome appears straightforward, there are no defined criteria to describe and grade the severity of hemolytic uremic syndrome or of the preceding gastrointestinal disease," Dr.
One week after the condition resolves, some patients may develop hemolytic uremic syndrome.