Management of delayed hemolytic transfusion reaction
in sickle cell disease: prevention, diagnosis, treatment.
This ensures that pretransfusion compatibility tests are robust and reproducible, providing patients with the highest level of protection against harmful hemolytic transfusion reactions
Alloantibody Indication for Transfusion detected transfusion reaction 1 Anti-K Anemia, Hb< 7g/dl No 2 Ant-C + D Painful crisis, DHTR (1), anemia jaundice 3 Anti-K Painful crisis, anemia DHTR, jaundice 4 Anti-C Joint pain, No painful crisis Anemia 5 Anti-D Anemia, Hb< 8g/dl IHTR (2), jaundice 6 Anti-E Anemia, joint pain No 7 Anti-K Anemia, Hb< 6g/dl Jaundice 8 Anti-E Anemia, painful crisis No 9 Anti-c Anemia, painful crisis Jaundice (1) DHTR: delayed hemolytic transfusion reactions
; (2) IHTR: immediate hemolytic transfusion reaction
Oakley, "An acute hemolytic transfusion reaction
caused by dog erythrocyte antigen 1.1 incompatibility in a previously sensitized dog," Journal of the American Veterinary Medical Association, vol.
Other labs were remarkable for elevated LDH (2009 mg/dL), reticulocytosis (absolute reticulocyte count: 354,576 cells/[mm.sup.3]), and a positive direct antiglobulin test suggesting a delayed hemolytic transfusion reaction
. Right upper quadrant ultrasound performed revealed innumerable hypoechoic hepatic masses (Figure 1).
Cyanuric-PEG was dePEGylated at a serum lactic acid level between 11.4 and 14.6 mMol/L which is very significant given that in vivo serum lactic acid levels above 4 mmol/L are associated with 11% survival in ICU patients if persistent for 24 hours, and the potential complications of a hemolytic transfusion reaction
superimposed on severe lactic acidosis would most likely ensure death.
A case of acute hemolytic transfusion reaction
due to anti-Dia antibody: A case report.
22-26% of A2B individuals can have anti A1 antibodies that react a temperature below 25 degrees and cause hemolytic transfusion reaction
. (1,2) We present a rare case of an A2B positive blood group with postpartum hemorrhage, DIC in hypovolemic shock.
An antibody is considered clinically significant if antibodies of its specificity have been associated with hemolytic disease of the fetus and newborn, with a hemolytic transfusion reaction
, or with a decrease in red blood cell survival.
Hemolytic transfusion reaction
. This reaction results from incompatibility of donor and recipient blood.
Because the antibodies formed in response to red cell transfusions or pregnancies tend to fade or disappear, a previously sensitized patient is a likely candidate for a delayed hemolytic transfusion reaction
with subsequent transfusions (26).