hemolytic transfusion reaction


Also found in: Acronyms.

hemolytic transfusion reaction

Transfusion medicine A therapy-related event mediated by 2 different mechanisms:
1. Intravascular hemolysis mediated by complement-fixing antibodies,.
2. Extravascular hemolysis mediated by noncomplement-fixing antibodies Clinical Fever, chills, pain at infusion site, intense back pain, hypotension, sense of impending doom, chest tightness, acute dyspnea, brochospasm, anaphylaxis, hyperbilirubinemia, hemoglobinuria, DIC with fibrinolysis Management Stop transfusion, treat shock–vasopressors, IV fluids, cortiocosteroids, maintain high fluid throughput, monitor anemia, transfuse with compatible blood.

hemolytic transfusion reaction

The destruction of donated and infused red blood cells by antibodies in the person receiving the transfusion.
See: transfusion reaction
References in periodicals archive ?
Management of delayed hemolytic transfusion reaction in sickle cell disease: prevention, diagnosis, treatment.
This ensures that pretransfusion compatibility tests are robust and reproducible, providing patients with the highest level of protection against harmful hemolytic transfusion reactions.
Alloantibody Indication for Transfusion detected transfusion reaction 1 Anti-K Anemia, Hb< 7g/dl No 2 Ant-C + D Painful crisis, DHTR (1), anemia jaundice 3 Anti-K Painful crisis, anemia DHTR, jaundice 4 Anti-C Joint pain, No painful crisis Anemia 5 Anti-D Anemia, Hb< 8g/dl IHTR (2), jaundice 6 Anti-E Anemia, joint pain No 7 Anti-K Anemia, Hb< 6g/dl Jaundice 8 Anti-E Anemia, painful crisis No 9 Anti-c Anemia, painful crisis Jaundice (1) DHTR: delayed hemolytic transfusion reactions; (2) IHTR: immediate hemolytic transfusion reaction.
Oakley, "An acute hemolytic transfusion reaction caused by dog erythrocyte antigen 1.1 incompatibility in a previously sensitized dog," Journal of the American Veterinary Medical Association, vol.
Other labs were remarkable for elevated LDH (2009 mg/dL), reticulocytosis (absolute reticulocyte count: 354,576 cells/[mm.sup.3]), and a positive direct antiglobulin test suggesting a delayed hemolytic transfusion reaction. Right upper quadrant ultrasound performed revealed innumerable hypoechoic hepatic masses (Figure 1).
Hemolytic Transfusion Reaction: Safeguards for Practice.
Cyanuric-PEG was dePEGylated at a serum lactic acid level between 11.4 and 14.6 mMol/L which is very significant given that in vivo serum lactic acid levels above 4 mmol/L are associated with 11% survival in ICU patients if persistent for 24 hours, and the potential complications of a hemolytic transfusion reaction superimposed on severe lactic acidosis would most likely ensure death.
A case of acute hemolytic transfusion reaction due to anti-Dia antibody: A case report.
22-26% of A2B individuals can have anti A1 antibodies that react a temperature below 25 degrees and cause hemolytic transfusion reaction. (1,2) We present a rare case of an A2B positive blood group with postpartum hemorrhage, DIC in hypovolemic shock.
An antibody is considered clinically significant if antibodies of its specificity have been associated with hemolytic disease of the fetus and newborn, with a hemolytic transfusion reaction, or with a decrease in red blood cell survival.
Hemolytic transfusion reaction. This reaction results from incompatibility of donor and recipient blood.
Because the antibodies formed in response to red cell transfusions or pregnancies tend to fade or disappear, a previously sensitized patient is a likely candidate for a delayed hemolytic transfusion reaction with subsequent transfusions (26).