hemolytic disease of the fetus and newborn

hemolytic disease of the fetus and newborn

alloimmune hemolytic anemia caused by placental transfer of IgG blood group antibodies from an immunized mother to the fetus, whose red cells carry an antigen inherited from the father. Hemolysis of fetal red cells can cause severe anemia, jaundice, and enlargement of the liver and spleen, which, without intervention, can lead to hypoxia, cardiac failure, generalized edema, respiratory distress, and death.
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The company collects high quality human blood plasma, the vital raw material that allows Kedrion Biopharma to produce and distribute plasma-derived therapeutic products for use in treating and/or preventing serious diseases and conditions such as hemophilia, primary immune system deficiencies and Rh sensitization which can lead to hemolytic disease of the fetus and newborn.
It was 1 year later that he published the use of the DAT as a method of demonstrating in vivo sensitization of RBCs in hemolytic disease of the fetus and newborn (HDFN).
This edition has been reorganized around sections on fundamental concepts; blood groups and serologic testing, including detection and identification of antibodies and pretransfusion testing; transfusion practice, with chapters on donor screening, component preparation, transfusion therapy, reactions, and apheresis, and discussion of hemolytic disease of the fetus and newborn, autoimmune hemolytic anemias, and transfusion-transmitted diseases; leukocyte antigens and relationship testing; quality and compliance issues, with discussion of quality management, safety and federal regulatory requirements, laboratory information systems, and legal and ethical issues; and future trends.
More than 50 different red-cell antigens are associated with hemolytic disease of the fetus and newborn (HDFN), but most cases of severe fetal disease are caused by anti-RhD, anti-RhC, and anti-Kell (K1) (1).
Daniels (Bristol Institute for Transfusion Services) and Bromilow (DiaMed AG) describe the ABO, Rh, Kell, Duffy, Kidd, MNS, Diego, and Lewis blood group systems, and explain the clinical significance of blood group antibodies causing hemolytic transfusion reaction and hemolytic disease of the fetus and newborn.
8 Anti-D: Basic Concepts and Mechanisms of Action in Hemolytic Disease of the Fetus and Newborn
Thus, they may not realize the potential consequences of underdosing RhIG, such as an increased risk of D alloimmunization and severe hemolytic disease of the fetus and newborn in future pregnancies.
Used in the prevention of hemolytic disease of the fetus and newborn (HDN), Rhophylac(R) provides a choice for physicians and patients who are concerned about the pain associated with IM administration, especially when multiple injections are required.
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