Hemoglobin
(redirected from hemoglobin concentration)Also found in: Dictionary, Thesaurus, Encyclopedia.
hemoglobin
[he´mo-glo″bin]the main functional constituent of the red blood cell, serving as the oxygen-carrying protein; it is a type of hemoprotein in which each molecule is a tetramer composed of four monomers held together by weak bonds. It consists of two pairs of polypeptide chains, the globins, each having an attached heme molecule composed of iron plus a protoporphyrin molecule. Symbol Hb.
Oxygenated hemoglobin (oxyhemoglobin) is bright red in color; hemoglobin unbound to oxygen (deoxyhemoglobin) is darker. This accounts for the bright red color of arterial blood, in which the hemoglobin is about 97 per cent saturated with oxygen. Venous blood is darker because it is only about 20 to 70 per cent saturated, depending on how much oxygen is being used by the tissues. The affinity of hemoglobin for carbon monoxide is 210 times as strong as its affinity for oxygen. The complex formed (carboxyhemoglobin) cannot transport oxygen. Thus, carbon monoxide poisoning results in hypoxia and asphyxiation.
Another form of hemoglobin that cannot transport oxygen is methemoglobin, in which the iron atom is oxidized to the +3 oxidation state. During the 120-day life span of a red blood cell, hemoglobin is slowly oxidized to methemoglobin. At least four different enzyme systems can convert methemoglobin back to hemoglobin. When these are defective or overloaded, methemoglobinemia can result, with high methemoglobin levels causing dyspnea and cyanosis.
A secondary function of hemoglobin is as part of the blood buffer system. The histidine residues in the globin chains act as weak bases to minimize the change in blood pH that occurs as oxygen is absorbed and carbon dioxide released in the lungs and as oxygen is delivered and carbon dioxide taken up from the tissues.
As erythrocytes wear out or are damaged, they are ingested by macrophages of the reticuloendothelial system. The porphyrin ring of heme is converted to the bile pigment bilirubin, which is excreted by the liver. The iron is transported to the bone marrow to be incorporated in the hemoglobin of newly formed erythrocytes.
The hemoglobin concentration of blood varies with the hematocrit. The normal values for the blood hemoglobin concentration are 13.5 to 18.0 g/100 ml in males and 12.0 to 16.0 g/100 ml in females. The normal mean corpuscular hemoglobin concentration, which is the concentration within the red blood cells, is 32 to 36 g/100 ml.
Chemistry and Physiology.
The iron atom has a free valence and can bind one molecule of oxygen. Thus, each hemoglobin molecule can bind one molecule of oxygen. The binding of oxygen by one monomer increases the affinity for oxygen of the others in the tetramer. This makes hemoglobin a more efficient transport protein than a monomeric protein such as myoglobin. Oxygenated hemoglobin (oxyhemoglobin) is bright red in color; hemoglobin unbound to oxygen (deoxyhemoglobin) is darker. This accounts for the bright red color of arterial blood, in which the hemoglobin is about 97 per cent saturated with oxygen. Venous blood is darker because it is only about 20 to 70 per cent saturated, depending on how much oxygen is being used by the tissues. The affinity of hemoglobin for carbon monoxide is 210 times as strong as its affinity for oxygen. The complex formed (carboxyhemoglobin) cannot transport oxygen. Thus, carbon monoxide poisoning results in hypoxia and asphyxiation.
Another form of hemoglobin that cannot transport oxygen is methemoglobin, in which the iron atom is oxidized to the +3 oxidation state. During the 120-day life span of a red blood cell, hemoglobin is slowly oxidized to methemoglobin. At least four different enzyme systems can convert methemoglobin back to hemoglobin. When these are defective or overloaded, methemoglobinemia can result, with high methemoglobin levels causing dyspnea and cyanosis.
A secondary function of hemoglobin is as part of the blood buffer system. The histidine residues in the globin chains act as weak bases to minimize the change in blood pH that occurs as oxygen is absorbed and carbon dioxide released in the lungs and as oxygen is delivered and carbon dioxide taken up from the tissues.
As erythrocytes wear out or are damaged, they are ingested by macrophages of the reticuloendothelial system. The porphyrin ring of heme is converted to the bile pigment bilirubin, which is excreted by the liver. The iron is transported to the bone marrow to be incorporated in the hemoglobin of newly formed erythrocytes.
The hemoglobin concentration of blood varies with the hematocrit. The normal values for the blood hemoglobin concentration are 13.5 to 18.0 g/100 ml in males and 12.0 to 16.0 g/100 ml in females. The normal mean corpuscular hemoglobin concentration, which is the concentration within the red blood cells, is 32 to 36 g/100 ml.
Variant and Abnormal Hemoglobins. There are six different types of globin chains, designated by the Greek letters α, β, γ, δ, ε, and ζ. The composition of a hemoglobin is specified by a formula such as α2β2, which indicates a tetramer containing two α chains and two β chains. The chains are coded by different genes, which are turned on and off during development in order to produce hemoglobins with the oxygen-carrying properties required at each developmental stage. In the first three months of embryonic development, when blood cells are produced in the yolk sac, embryonic hemoglobins such as Hb Gower (α2Aε2) or Hb Portland (ζ2γ2) are produced. As erythropoiesis shifts to the liver and spleen, the fetal hemoglobin Hb F (α2γ2) appears. When erythropoiesis shifts to the bone marrow during the first year of life, the adult hemoglobins Hb A (α2β2) and Hb A2 (α2δ2) begin to be produced.
Many abnormal hemoglobins arising from mutations have been discovered. Some have altered oxygen affinity, some are unstable, and in some the iron atom is oxidized, resulting in congenital methemoglobinemia. Some mutations result in a reduced rate of hemoglobin synthesis. All such conditions are known as hemoglobinopathies.
The most common hemoglobinopathy is sickle cell disease, caused by a mutation replacing the sixth amino acid in the β chain, normally glutamic acid, by valine. The variant hemoglobin α2βS2 is known as Hb S. Mutations resulting in reduced synthesis of one of the chains are called thalassemias. They can result from deletion of the gene for a chain or from a mutation in the regulatory gene that controls the synthesis of the chain.
Many abnormal hemoglobins arising from mutations have been discovered. Some have altered oxygen affinity, some are unstable, and in some the iron atom is oxidized, resulting in congenital methemoglobinemia. Some mutations result in a reduced rate of hemoglobin synthesis. All such conditions are known as hemoglobinopathies.
The most common hemoglobinopathy is sickle cell disease, caused by a mutation replacing the sixth amino acid in the β chain, normally glutamic acid, by valine. The variant hemoglobin α2βS2 is known as Hb S. Mutations resulting in reduced synthesis of one of the chains are called thalassemias. They can result from deletion of the gene for a chain or from a mutation in the regulatory gene that controls the synthesis of the chain.
The life cycle of red blood cells and the breakdown of hemoglobin. From Polaski and Tatro, 1996.
hemoglobin A1c hemoglobin A with a glucose group attached to the amino terminal of the beta chain; it is made at a slow constant rate during the 120-day life span of the erythrocyte. It accounts for 3 to 6 per cent of the total hemoglobin in a normal person and up to 12 per cent in persons with diabetes mellitus. Increased levels correlate with glucose intolerance in diabetics; with good diabetic control its level returns to normal range, so that periodic assays can be helpful in evaluating effective control of diabetes.
glycated hemoglobin (glycosylated hemoglobin) any of various hemoglobins with glucose attached nonenzymatically; the most common one is hemoglobin A1c. The percentage of hemoglobin that is glycosylated can be assessed over a long period of time as a gauge of blood sugar control; the normal range for a nondiabetic person is between 4 and 6 per cent.
mean corpuscular hemoglobin (MCH) the average hemoglobin content of an erythrocyte, conventionally expressed in picograms per red cell, obtained by multiplying the blood hemoglobin concentration (in g/dl) by 10 and dividing by the red cell count (in millions per ml): MCH = Hb/RBC.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
he·mo·glo·bin (Hb, Hgb),
(hē'mō-glō'bin), [MIM*141800-142310]The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin, with a molecular weight of 64,450, which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb. When Hb is exposed to certain chemicals, its normal respiratory function is blocked; for example, the oxygen in HbO2 is easily displaced by carbon monoxide, thereby resulting in the formation of fairly stable carboxyhemoglobin (HbCO), as in asphyxiation resulting from inhalation of exhaust fumes from gasoline engines. When the iron in Hb is oxidized from the ferrous to ferric state, as in poisoning with nitrates and certain other chemicals, a nonrespiratory compound, methemoglobin (MetHb), is formed.
In humans there are at least five kinds of normal Hb: two embryonic Hb's (Hb Gower-1, Hb Gower-2), fetal (Hb F), and two adult types (Hb A, Hb A2). There are two α globin chains containing 141 amino acid residues, and two of another kind (β, γ, δ, ε, or ζ), each containing 146 amino acid residues in four of the Hb's. Hb Gower-1 has two ζ chains and two ε chains. The production of each kind of globin chain is controlled by a structural gene of similar Greek letter designation; normal individuals are homozygous for the normal allele at each locus. Substitution of one amino acid for another in the polypeptide chain can occur at any codon in any of the five loci and have resulted in the production of many hundreds of abnormal Hb types, most of no known clinical significance. In addition, deletions of one or more amino acid residues are known, as well as gene rearrangements due to unequal crossing over between homologous chromosomes.
The Hb types below are the main abnormal types known to be of clinical significance. Newly discovered abnormal Hb types are first assigned a name, usually the location where discovered, and a molecular formula is added when determined. The formula consists of Greek letters to designate the basic chains, with subscript 2 if there are two identical chains; a superscript letter (A if normal for adult Hb, etc.) is added, or the superscript may designate the site of amino acid substitution (numbering amino acid residues from the N-terminus of the polypeptide) and specifying the change, using standard abbreviations for the amino acids. There is an exhaustive listing of variant Hb's in MIM in which a composite numbering system is used.
In humans there are at least five kinds of normal Hb: two embryonic Hb's (Hb Gower-1, Hb Gower-2), fetal (Hb F), and two adult types (Hb A, Hb A2). There are two α globin chains containing 141 amino acid residues, and two of another kind (β, γ, δ, ε, or ζ), each containing 146 amino acid residues in four of the Hb's. Hb Gower-1 has two ζ chains and two ε chains. The production of each kind of globin chain is controlled by a structural gene of similar Greek letter designation; normal individuals are homozygous for the normal allele at each locus. Substitution of one amino acid for another in the polypeptide chain can occur at any codon in any of the five loci and have resulted in the production of many hundreds of abnormal Hb types, most of no known clinical significance. In addition, deletions of one or more amino acid residues are known, as well as gene rearrangements due to unequal crossing over between homologous chromosomes.
The Hb types below are the main abnormal types known to be of clinical significance. Newly discovered abnormal Hb types are first assigned a name, usually the location where discovered, and a molecular formula is added when determined. The formula consists of Greek letters to designate the basic chains, with subscript 2 if there are two identical chains; a superscript letter (A if normal for adult Hb, etc.) is added, or the superscript may designate the site of amino acid substitution (numbering amino acid residues from the N-terminus of the polypeptide) and specifying the change, using standard abbreviations for the amino acids. There is an exhaustive listing of variant Hb's in MIM in which a composite numbering system is used.
Farlex Partner Medical Dictionary © Farlex 2012
hemoglobin
(hē′mə-glō′bĭn)n.
The protein in the red blood cells of vertebrates that carries oxygen from the lungs to tissues and that consists of four polypeptide subunits, each of which is bound to an iron-containing heme molecule.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
hemoglobin
Hb Physiology A tetrameric 64 kD protein that is the major constituent of RBCs, which transports O2, and buffers CO2 produced by respiration; Hb transports O2 and CO2 and which comprises 99% of the protein weight of RBCs; it is composed of 2 α chains, each 141 amino acids in length, encoded from the zeta chain gene on chromosome 16 and 2 β chains, each 144 amino acids in length, encoded from the contiguous eta, Gγ, Aγ and delta chain genes on chromosome 11 Forms of Hb HbF is formed in the fetus and is the major Hb until birth; at birth up to 30% of the hemoglobin is HbA; most adult Hb is HbA with small amounts of HbF and HbA2; Hb defects are inherited and termed hemoglobinopathies. See Carboxyhemoglobin, Chemically modified hemoglobin, Fetal hemoglobin, Reduced hemoglobin.McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
he·mo·glo·bin
(Hgb, Hb) (hē'mō-glō'bin)The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin, with a molecular weight of 64,450, which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb. When Hb is exposed to certain chemicals, its normal respiratory function is blocked; thus, oxygen in HbO2 is easily displaced by carbon monoxide, a process that results in the formation of fairly stable carboxyhemoglobin (HbCO), as in asphyxiation resulting from inhalation of exhaust fumes from gasoline engines. When the iron in Hb is oxidized from the ferrous to ferric state, as in poisoning with nitrates and certain other chemicals, a nonrespiratory compound, methemoglobin (MetHb), is formed.
Synonym(s): haemoglobin.
Synonym(s): haemoglobin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
hemoglobin
(he'mo-glo?bin) [ hem- + globin],Hb, Hbg, Hgb
The iron-containing pigment of red blood cells (RBCs) that carries oxygen from the lungs to the tissues. The amount of hemoglobin in the blood averages 12 to 16 g/100 ml in women, 14 to 18 g/100 ml in men, and somewhat less in children. Hemoglobin is a crystallizable, conjugated protein consisting of heme and globin. In the lungs, 1 g of hemoglobin combines readily with 1.36 cc of oxygen by oxygenation to form oxyhemoglobin. In the tissues where oxygen concentration is low and carbon dioxide (CO2) concentration is high (low pH), hemoglobin releases its oxygen. Hemoglobin also acts as a buffer for the hydrogen ions produced in RBCs when (CO2) is converted to bicarbonate ions for transport in the plasma.
When old RBCs are phagocytized by macrophages in the liver, spleen, and red bone marrow, the iron of hemoglobin is reused immediately to produce new RBCs or is stored in the liver until needed. The globin is converted to amino acids for the synthesis of other proteins. The heme portion is of no further use and is converted to bilirubin.
Hemoglobin combines with carbon monoxide (in carbon monoxide poisoning) to form the stable compound carboxyhemoglobin, which renders hemoglobin unable to bond with oxygen and results in hypoxia of tissues. Oxidation of the ferrous iron of hemoglobin to the ferric state produces methemoglobin.
Hundreds of different types of hemoglobin have been discovered. See: blood
)
HEMOGLOBIN A MOLECULE
hemoglobin A
A hemoglobin molecule composed of two alpha and two beta chains.
See: illustrationhemoglobin A1c
Abbreviation: Hb A1cHemoglobin A that contains a glucose group linked to the terminal amino acid of the beta chains of the molecule. Levels of hemoglobin A1c can be used to determine both the presence of diabetes mellitus (in previously undiagnosed patients) and the degree of glycemic control of known diabetics. The amount of glucose bound to the hemoglobin depends on the average concentration of glucose in the blood over time. In patients with diabetes mellitus, when the blood glucose level is optimally and carefully regulated over 8 to 12 weeks, the Hb A1c level is normal or slightly elevated. If the blood glucose level has not been controlled (and has been abnormally elevated) in the preceding 8 to 12 weeks, the Hb A1c blood level is increased. Hb A1c is a good indicator of long-term glycemic control. The blood test for it may be performed when the patient is not fasting. Synonym: glycohemoglobin; glycated hemoglobin; glycosylated hemoglobin
Barts hemoglobin
See: Barts hemoglobinhemoglobin C
A hemoglobin molecule in which lysine is substituted for glutamic acid at the sixth position of the beta chain. This substitution decreases the solubility of the hemoglobin molecule and increases the rigidity of the red blood cell membrane.
hemoglobin E
A hemoglobin molecule in which lysine is substituted for glutamic acid at the 26th position of the beta chain. This variation is found most often in those of Southeast Asian ancestry.
fetal hemoglobin
The type of hemoglobin found in the erythrocytes of the normal fetus. It has better oxygen-binding capacity than adult hemoglobin and is able to extract oxygen from the placenta to meet the needs of the fetus.
Patient care
The induction of fetal hemoglobin (with drugs such as hydroxyurea) in patients with sickle cell anemia often improves their clinical status because fetal hemoglobin does not deform or “sickle” in the circulation. It is capable of taking up and giving off oxygen at lower oxygen tensions than the hemoglobin in adult erythrocytes.
free plasma hemoglobin
Plasma hemoglobin.glycated hemoglobin
Hemoglobin A1c.glycosylated hemoglobin
Hemoglobin A1c.hemoglobin Lepore
A variant hemoglobin formed by an unequal crossover and fusion of the beta and delta genes. A single copy of the variant gene causes thalassemia minor. Homozygotes have thalassemia intermedia.
mean cell hemoglobin
The hemoglobin content of the average RBC, usually expressed in picograms per red cell and calculated by multiplying the number of grams of hemoglobin/100 ml by 10 and dividing by the red cell count.
Synonym: mean corpuscular hemoglobinmean corpuscular hemoglobin
Abbreviation: MCHMean cell hemoglobin.
plasma hemoglobin
Hemoglobin released from red blood cells when they are destroyed (lyzed). It circulates in the blood and extravascular tissues. Synonym: free plasma hemoglobin
Medical Dictionary, © 2009 Farlex and Partners
Hemoglobin (Hb)
An iron-containing pigment of red blood cells composed of four amino acid chains (alpha, beta, gamma, delta) that delivers oxygen from the lungs to the tissues of the body.
Mentioned in: Anemias, Anoxia, Antianemia Drugs, Biliary Atresia, Blood Gas Analysis, Carbon Monoxide Poisoning, Coombs' Tests, Cyanosis, Erythroblastosis Fetalis, Haptoglobin Test, Hematocrit, Hemoglobin Test, Hemoglobinopathies, Iron Deficiency Anemia, Jaundice, Liposuction, Multiple Myeloma, Neonatal Jaundice, Platelet Function Disorders, Porphyrias, Sickle Cell Disease, Thalassemia, 2,3-Diphosphoglycerate Test
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
he·mo·glo·bin
(Hb) (hē'mō-glō'bin) [MIM*141800142310, MIM*141800]Red respiratory protein of erythrocytes. In humans, there are at least five kinds of normal Hb: two embryonic Hbs (Hb Gower-1, Hb Gower-2), fetal (Hb F), and two adult types (Hb A, Hb A2).
Synonym(s): haemoglobin.
Synonym(s): haemoglobin.
Medical Dictionary for the Dental Professions © Farlex 2012
Patient discussion about Hemoglobin
Q. Can Jantoven cause hemoglobin to drop?
A. Yes. In that case, you may consider consulting a doctor, since it may result from bleeding that may necessitate treatment.
Q. What is the Definition of Anemia? My doctor told me I have anemia, based on my latest blood tests. What is anemia?
A. In laymans terms it is low iron. Most women get it sometime in their lives due to menstration and other factors. You need to increase your iron intake. Lots of beets, beans, spinich, and lots of other foods can help.
More discussions about HemoglobinThis content is provided by iMedix and is subject to iMedix Terms. The Questions and Answers are not endorsed or recommended and are made available by patients, not doctors.