hemoglobin SC disease

hemoglobin SC disease

Hematology A sickling disorder resulting from inheritance of a HbS gene from one parent and a HbC gene from the other; RBCs contain ± equal amounts of each Hb; HbA is absent; HbF may be ↑ Clinical Similar to, but less severe than, sickle cell anemia; by preadolescence, episodic skeletal or abdominal pain, moderate splenomegaly; unique to SC disease is an ↑ risk of retinal disease–proliferative retinopathy, retinal vascular disease, aseptic necrosis of femoral head, acute chest syndrome after fat embolism due to bone infarction. See Sickle cell anemia.

hemoglobin SC disease

A disease of those who have inherited two abnormal forms of hemoglobin, S and C. The affected may have vaso-occlusive crises similar to those seen in sickle cell anemia, with bony and visceral infarcts.
References in periodicals archive ?
Hemoglobin SC disease, is a type of sickle cell disease, which means it affects the shape of the red blood cells.
This is a unique case of massive ovarian edema caused by a vasoocclusive crisis in a girl with hemoglobin SC disease.
Hemoglobin SC disease and hemoglobin S[[beta].sup.+] thalassemia are other common forms of SCD.
Functional asplenia in hemoglobin SC disease. Blood 1995 Apr; 85(8):2238-2244.
In hemoglobin SC disease (HbSC), there is an association of HbS with another hemoglobin variant, HbC ([[beta].sup.C]), that results in a typically milder form of SCD [1].
Sickle cell anemia (HbSS/HbS-Beta thalassemia zero) accounts for 70% of cases of sickle cell disease in populations of African ethnicity, with most of the remainder having hemoglobin SC disease (HBSC disease) due to the coinheritance of the [[beta].sup.s] and [[beta].sup.c] alleles [2,3].
Mobile Right Atrial Thrombi in a Patient with the Hemoglobin SC Disease. Case Rep Med.
Chronic granulocytic leukemia in a patient with hemoglobin SC disease. Americal Journal of Hematology 1989; 31: 302.
Hemoglobin SC disease. Am J Hematol 1997; 54(4):313.
Hydroxyurea therapy for pediatric patients with hemoglobin SC Disease. Journal of Pediatric Hematology/Oncology, 23(5), 306-308.
This rare neoplasm has been associated with sickle cell trait in all reported cases but one in which the patient had hemoglobin SC disease. This condition has been described as the "seventh sickle cell nephropathy" in reference to the original 6 identified by Berman in 1974.
Sickle-cell anemia [Beta] globin Hemoglobin C disease [Beta] globin Hemoglobin SC disease [Beta] globin Hemoglobin E disease [Beta] globin Hemoglobin D disease [Beta] globin [Beta] thalassemias [Beta] globin [Alpha] thalassemias [Alpha] globin Hereditary persistence [Gamma] globin of fetal hemoglobin (HPFH) Hemoglobinopathies associated with [Alpha] chain predominantly unstable hemoglobins