hemoglobin SC disease
hemoglobin SC (Hb SC) disease
a genetic anemia in which abnormal alleles, one for hemoglobin S and one for hemoglobin C, are inherited. The disorder is characterized by a clinical course considerably less severe than that of sickle cell anemia despite the absence of normal hemoglobin. Also called sickle cell-hemoglobin C disease. See also hemoglobin C disease, sickle cell anemia.
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Hemoglobin SC disease
hemoglobin SC disease
Hematology A sickling disorder resulting from inheritance of a HbS gene from one parent and a HbC gene from the other; RBCs contain ± equal amounts of each Hb; HbA is absent; HbF may be ↑ Clinical Similar to, but less severe than, sickle cell anemia; by preadolescence, episodic skeletal or abdominal pain, moderate splenomegaly; unique to SC disease is an ↑ risk of retinal disease–proliferative retinopathy, retinal vascular disease, aseptic necrosis of femoral head, acute chest syndrome after fat embolism due to bone infarction. See Sickle cell anemia.hemoglobin SC disease
A disease of those who have inherited two abnormal forms of hemoglobin, S and C. The affected may have vaso-occlusive crises similar to those seen in sickle cell anemia, with bony and visceral infarcts.