hemoglobin SC disease

hemoglobin SC (Hb SC) disease

a genetic anemia in which abnormal alleles, one for hemoglobin S and one for hemoglobin C, are inherited. The disorder is characterized by a clinical course considerably less severe than that of sickle cell anemia despite the absence of normal hemoglobin. Also called sickle cell-hemoglobin C disease. See also hemoglobin C disease, sickle cell anemia.
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Hemoglobin SC disease

hemoglobin SC disease

Hematology A sickling disorder resulting from inheritance of a HbS gene from one parent and a HbC gene from the other; RBCs contain ± equal amounts of each Hb; HbA is absent; HbF may be ↑ Clinical Similar to, but less severe than, sickle cell anemia; by preadolescence, episodic skeletal or abdominal pain, moderate splenomegaly; unique to SC disease is an ↑ risk of retinal disease–proliferative retinopathy, retinal vascular disease, aseptic necrosis of femoral head, acute chest syndrome after fat embolism due to bone infarction. See Sickle cell anemia.

hemoglobin SC disease

A disease of those who have inherited two abnormal forms of hemoglobin, S and C. The affected may have vaso-occlusive crises similar to those seen in sickle cell anemia, with bony and visceral infarcts.
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References in periodicals archive ?
Mobile Right Atrial Thrombi in a Patient with the Hemoglobin SC Disease.
Intracardiac thrombosis in sickle cell disease
Chronic granulocytic leukemia in a patient with hemoglobin SC disease.
Possibility of Leukogenicity effect of long term use of hydroxyurea in sickle cell Anaemia
Hydroxyurea therapy for pediatric patients with hemoglobin SC Disease.
Hydroxyurea therapy: improving the lives of patients with sickle cell disease
A 36-year-old black male with a history of hemoglobin SC disease presented with severe left hip pain.
In one large series of children with hemoglobin SC disease, only 5% had episodes of acute splenic sequestration.
Case report: splenic infarction and acute splenic sequestration in adults with hemoglobin SC disease.
Hemoglobin SC disease revisited: clinical study of 106 adults.
Splenic infarction, splenic sequestration, and functional hyposplenism in hemoglobin SC disease.
Acute splenic sequestration crisis resembling sepsis in an adult with hemoglobin SC disease
Sickle-cell anemia [Beta] globin Hemoglobin C disease [Beta] globin Hemoglobin SC disease [Beta] globin Hemoglobin E disease [Beta] globin Hemoglobin D disease [Beta] globin [Beta] thalassemias [Beta] globin [Alpha] thalassemias [Alpha] globin Hereditary persistence [Gamma] globin of fetal hemoglobin (HPFH) Hemoglobinopathies associated with [Alpha] chain predominantly unstable hemoglobins
Pioneering advances in molecular hematology
Other types of sickle cell disease include hemoglobin SC disease and sickle beta-thalassemia; there are also other, less common types of sickle cell disease.
Sickle cell disease in newborns and infants: a guide for parents

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