hemoglobin SC disease

hemoglobin SC (Hb SC) disease

a genetic anemia in which abnormal alleles, one for hemoglobin S and one for hemoglobin C, are inherited. The disorder is characterized by a clinical course considerably less severe than that of sickle cell anemia despite the absence of normal hemoglobin. Also called sickle cell-hemoglobin C disease. See also hemoglobin C disease, sickle cell anemia.
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Hemoglobin SC disease

hemoglobin SC disease

Hematology A sickling disorder resulting from inheritance of a HbS gene from one parent and a HbC gene from the other; RBCs contain ± equal amounts of each Hb; HbA is absent; HbF may be ↑ Clinical Similar to, but less severe than, sickle cell anemia; by preadolescence, episodic skeletal or abdominal pain, moderate splenomegaly; unique to SC disease is an ↑ risk of retinal disease–proliferative retinopathy, retinal vascular disease, aseptic necrosis of femoral head, acute chest syndrome after fat embolism due to bone infarction. See Sickle cell anemia.

hemoglobin SC disease

A disease of those who have inherited two abnormal forms of hemoglobin, S and C. The affected may have vaso-occlusive crises similar to those seen in sickle cell anemia, with bony and visceral infarcts.
References in periodicals archive ?
Mobile Right Atrial Thrombi in a Patient with the Hemoglobin SC Disease.
Chronic granulocytic leukemia in a patient with hemoglobin SC disease.
Hydroxyurea therapy for pediatric patients with hemoglobin SC Disease.
Sickle-cell anemia [Beta] globin Hemoglobin C disease [Beta] globin Hemoglobin SC disease [Beta] globin Hemoglobin E disease [Beta] globin Hemoglobin D disease [Beta] globin [Beta] thalassemias [Beta] globin [Alpha] thalassemias [Alpha] globin Hereditary persistence [Gamma] globin of fetal hemoglobin (HPFH) Hemoglobinopathies associated with [Alpha] chain predominantly unstable hemoglobins
Other types of sickle cell disease include hemoglobin SC disease and sickle beta-thalassemia; there are also other, less common types of sickle cell disease.