hemoglobin Bart

he·mo·glo·bin Bart

[MIM*142309]

a Hb homotetramer (all four polypeptides identical) of formula γ₄, found in the early embryo and in α-thalassemia 2; not effective in oxygen transport; does not display a Bohr effect.

hemo·glo·bin Bart

(hē'mō-glō'bin bahrt)

An Hb homotetramer (all four polypeptides identical) of formula γ₄, found in the early embryo and in α-thalassemia 2; not effective in oxygen transport; does not display a Bohr effect.
Synonym(s): haemoglobin Bart.

References in periodicals archive ?

It is present in two clinically significant forms: hemoglobin Bart hydrops fetalis (Hb Bart) syndrome and hemoglobin H (HbH) disease.

Alpha thalassemia deletions found in suspected cases of beta thalassemia major in Pakistani population

Since [alpha]-globin chains are absent, hemoglobin F cannot be synthesized and hemoglobin Bart's becomes the dominant hemoglobin.

A case of nonimmune hydrops fetalis caused by homozygous [alpha]-thalassemia / Homozigot [alpha]-Talasemiye Bagli Gelisen Bir Nonimmun Hidrops Fetalis Olgusu

In some cases, a small amount of hemoglobin Bart's may be present.

Diagnosis of Hemoglobin H Disease

Sonographic markers of hemoglobin Bart disease at midpregnancy.

A multiplex quantitative fluorescent PCR test for prenatal diagnosis of Hb baits hydrops fetalis