hemoglobin A2


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he·mo·glo·bin A2

[MIM*141850]
the normal Hb (Hb A2) of the formula α2Aδ2 or α2δ2, which makes up approximately 2.5% of the total adult hemoglobin concentration. At least 18 mutant variants of the δ chain have been reported.

hemoglobin A2 (Hb A2)

a normal hemoglobin present in small amounts in adults, characterized by the substitution of delta chains for beta chains. Its concentration in the blood increases in various hematologic diseases. It normally constitutes 1.5% to 3.5% of the total hemoglobin.
References in periodicals archive ?
Phenotypic expression of hemoglobin A2 in beta-thalassemia trait with iron deficiency.
6 Normal Person Sickle-cell syndrome P1 ([female]) HbAS P2 ([male]) HbAS/[alpha] thal P3 ([male]) HbAS/[beta] thal P4 ([male]) HbAS/[alpha] thal P5 ([female]) HbAS P6 ([female]) HbAS P7 ([male]) HbAS/[beta] thal References: Solubility: Reference value: negative, positive sickle cells: presence of drepanocytes; Electrophoresis: Values: Hemoglobin A1 (96-98%); Hemoglobin A2 (2.
Significance of borderline hemoglobin A2 values in an Italian population with a high prevalence of [beta]-thalassemia," Haematologica, vol.
The range of hemoglobin A2 in hemoglobin E heterozygotes as determined by capillary electrophoresis.
A small percentage of hemoglobin A2 and hemoglobin F is also present in the population, Hemoglobin F is predominately in fetuses and newborns.
Hemoglobin A2 was analyzed by micro column technique from Bio Systems kits and hemoglobin F was assayed by alkaline denaturation technical.
Hemoglobin A2 duzeyi ise olgularin %95'inde artmistir (>%3,4).
Quantification of hemoglobin A2 by tandem mass spectrometry.
Results: A total of one hundred and thirty-five individuals with hypochromic microcytic anemia having normal hemoglobin F and hemoglobin A2 3.
In both alpha and beta thalassemia, significant mi-crocytosis (decreased MCV and/or MCH) is usually present, and in beta thalassemia, elevations in hemoglobin A2 are also usually detected.