Furthermore, when hemisection
with retention of one unit is planned, Cone-beam CT may help avoid or reduce treatment times by allowing the clinician to assess pre-operatively which unit to retain based on the three-dimensional anatomy of the double tooth.
Neuhuber et al (53) grafted human MSC derived from aspirates of four different donors into a subtotal cervical hemisection in adult female rats and found that cells integrated well into the injury site, with little migration away from the graft.
CB cells showed benefit in functional recovery after spinal cord hemisection in rats and suggested that [CD34.
Intraspinal transplantation of CD34+ human umbilical cord blood cells after spinal cord hemisection injury improves functional recovery in adult rats.
Transplants of adrenal medullary chromaffin cells reduce forelimb and hindlimb allodynia in a rodent model of chronic central pain after spinal hemisection injury.
Engraftment of immortalized serotonergic neurons enhances locomotor function and attenuates pain-like behavior following spinal hemisection injury in the rat.
Subdural engraftment of serotonergic neurons following spinal hemisection restores spinal serotonin, downregulates the serotonin transporter, and increases BDNF tissue content in the rat.
Hains BC, Chastain KM, Everhart AW, McAdoo DJ, Hulsebosch CE, "Transplants of Adrenal Medullary Chromaffin Cells Reduce Fore Limb and Hind Limb Allodynia in a Rodent Model of Chronic Central Pain after Spinal Cord Hemisection
We are very excited that results from the most applicable injury model to humans, the contusion model, appear to confirm our findings in the hemisection
model," said Rick Layer, PhD, Research & Development Manager at InVivo Therapeutics.
After midthoracic SCI, we found that the rats had mechanical allodynia in both their hindlimbs and forelimbs, as has been observed previously after either hemisection or contusion injury at this level [36,48].
Also, when the Nogo-66 receptor, which inhibits axonal growth, is blocked with intrathecal NgR(310)ecto-Fc protein after midthoracic bilateral dorsal hemisection, improved locomotion is accompanied by increased sprouting of both raphe-spinal and corticospinal axons .
In 1929, Pike and colleagues observed spontaneous hind limb recovery after spinal cord hemisection
in cats and proposed that "the mechanism which takes over control of movements of the limb lying below the level of the lesion includes motor fibers coming down on the opposite side of the spinal cord, and commissural neurons lying in the spinal cord below the level of the lesion" .