heme synthetase

Also found in: Dictionary, Thesaurus, Encyclopedia.

heme synthetase

The enzyme that catalyzes the chelation of iron (Fe++) to porphyrin, a crucial step in the synthesis of heme.
Synonym: ferrochelatase.


the nonprotein, insoluble, iron protoporphyrin constituent of hemoglobin, of various other respiratory pigments, and of many cells, both animal and vegetable. It is an iron compound of protoporphyrin and so constitutes the pigment portion or protein-free part of the hemoglobin molecule, and is responsible for its oxygen-carrying properties.

heme pigment nephropathy
see hemoglobinuric nephrosis.
heme synthetase
the rate-controlling enzyme for the synthesis of heme.