In this regard, experimental data available indicate that many pesticides may also possess hematotoxic
properties, leading to depressed hematopoiesis (3-5).
Evidence from animal carcinogenicity data and mechanistic data has also recently been made available, specifically for benzene (IARC 2018), showing the capacity of this compound to generate reactive electrophilic metabolites, induce oxidative stress, and DNA damage as well as immunotoxic and hematotoxic
These values corresponded to the NOAELs for hematotoxic
effects, from experimental study on rats and rabbits published by Barbee et al.
Our patient suffered from both neurotoxic and hematotoxic
features immediately after the event and presented 4 weeks later with features of pituitary insufficiency.
Acquired aplastic anemia (AA) is caused by destruction of hematopoietic stem cell (HSC) and progenitor cells associated with MSC abnormalities, caused by hematotoxic
agents (drugs, chemical agents, radiation, and virus).
We speculate that MSCs may be implicated in the initiation, development, and various aspects of hematotoxic
damage induced by benzene and its metabolites.
In general, venoms are described as either neurotoxic or hematotoxic
. (12) Cobra and krait envenomation is typically neurotoxic, whereas envenomation by Viperidae species shows characteristic vasculotoxic and haematotoxic features.
In this study a short-chain EGEs (ME and EE) in a relatively low dose (1.25 mM/kg/day) exerted weak hematotoxic
effects evidenced by reduction in RBC, PCV, HGB, WBC and LYM in peripheral blood.
and hepatotoxic effects of dichlorvos at sublethal dosages in rats.
However, the rapid deterioration of health of this patient prompted us to choose a liposomal form which is known to be less cardio and hematotoxic
. Only pegylated liposomal doxorubicin has been tested in children, in a phase I study .
Absence of hematotoxic
effect in the presence of CPE or PR