In this regard, experimental data available indicate that many pesticides may also possess
hematotoxic properties, leading to depressed hematopoiesis (3-5).
Evidence from animal carcinogenicity data and mechanistic data has also recently been made available, specifically for benzene (IARC 2018), showing the capacity of this compound to generate reactive electrophilic metabolites, induce oxidative stress, and DNA damage as well as immunotoxic and
hematotoxic effects.
These values corresponded to the NOAELs for
hematotoxic effects, from experimental study on rats and rabbits published by Barbee et al.
The most common alterations in these groups were Ht (+), MCHC (-), RBC (+), and WBC (+), which could be explained by the presence of chronic diseases in age groups, the possible use of
hematotoxic drugs, chronic exposure to OPCP, longer exposure in relation to the amount of worked days, and the meters above sea level of the housing site.
Our patient suffered from both neurotoxic and
hematotoxic features immediately after the event and presented 4 weeks later with features of pituitary insufficiency.
Acquired aplastic anemia (AA) is caused by destruction of hematopoietic stem cell (HSC) and progenitor cells associated with MSC abnormalities, caused by
hematotoxic agents (drugs, chemical agents, radiation, and virus).
We speculate that MSCs may be implicated in the initiation, development, and various aspects of
hematotoxic damage induced by benzene and its metabolites.
In general, venoms are described as either neurotoxic or
hematotoxic. (12) Cobra and krait envenomation is typically neurotoxic, whereas envenomation by Viperidae species shows characteristic vasculotoxic and haematotoxic features.
In this study a short-chain EGEs (ME and EE) in a relatively low dose (1.25 mM/kg/day) exerted weak
hematotoxic effects evidenced by reduction in RBC, PCV, HGB, WBC and LYM in peripheral blood.
Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats.
However, the rapid deterioration of health of this patient prompted us to choose a liposomal form which is known to be less cardio and
hematotoxic. Only pegylated liposomal doxorubicin has been tested in children, in a phase I study [4].
Absence of
hematotoxic effect in the presence of CPE or PR
