The Company's most advanced program is in the area of cell therapy, where work is underway to develop potential products for soft tissue cosmesis, hematopoietic
support in bone marrow transplantation, bone repair and cartilage repair.
Cellerant's CLT-008, a manufactured cell product derived from adult hematopoietic
stem cells, has been shown in numerous animal models to be protective against neutropenia caused by radiation or chemotherapy.
The patent allowance provides coverage to Pluristem's concept of creating a three-dimensional bone-like environment that supports expansion of hematopoietic
stem cell form cord blood samples while minimizing their differentiation into more mature cells that cannot be transplanted into the patient and reconstituted his blood and immune system.
PLX-1, which consists of propagated (adjuvant engineered) mesenchymal stem cells (MSC) that can be co-transplanted along with the hematopoietic
stem cells (HSC), is expected to significantly improve the engraftment rate of the HSCs.
Ora Burger, Vice President of Development, stated, "Pluristem has literally reinvented the process of hematopoietic
stem cell expansion and engraftment through its novel approach.
As a leader in the field of hematopoietic
stem cell research, Dr.
This agreement lays the groundwork for Centre Leon Berard to implement clinical trials initiated by SyStemix for the use of hematopoietic
stem cells as an adjunct to cancer chemotherapy and bone marrow transplantation.
This in-vivo model is based on the known ability of human Hematopoietic
stem cells to engraft in mouse bone marrow and to enable recovery of the mouse's immune system.
headquartered in Palo Alto, is developing a spectrum of cellular processes and products based on hematopoietic
stem cells (HSCs -- the source of all blood and immune system cells), gene-modified stem cells and other hematopoietic
Food and Drug Administration (FDA) completed review of the Company's Investigational New Drug (IND) application for the use of recombinant human Mannose-Binding Lectin (rhMBL) for the prevention and treatment of severe infections in patients with multiple myeloma with low levels of MBL undergoing high-dose chemotherapy and hematopoietic
stem cell transplantation.
We will take the opportunity to address our colleagues in the scientific community that sufficient engraftment is definitely possible with a limited number of hematopoietic
stem cells available in a single portion of umbilical cord blood.
Repopulation of neutrophils, platelets and red blood cells at about day 15 following irradiation demonstrated an accelerated recovery of the bone marrow that occurs by stimulation of hematopoietic
stem or progenitor cells.