Decreased platelet count is the most common and best recognized hematologic effect
of valproic acid; the incidence varies from 5% to 40%.
Side effects of VPA include GI distress (eg, anorexia, nausea, dyspepsia, vomiting, diarrhea), hematologic effects
(reversible leukopenia, thrombocytopenia), hair loss, weight gain, tremor, hepatic effects (benign LFT elevations, hepatotoxicity), osteoporosis, and sedation.
CONTEXT: Although there are ample data on the respiratory effects of exposure to fire extinguisher gas, the potential hematologic effects
have not been fully documented.
Special Considerations: Gastrointestinal tract symptoms (vomiting, nausea, and diarrhea); hematologic effects
(anemia, leukopenia, thrombocytopenia, neutropenia, and febrile neutropenia); and infection were the most common adverse events in a clinical study of 113 pediatric patients.
The hematologic effects
of hydroxyurea are the same in children [as in adults], perhaps better," Dr.
, such as thrombotic thrombocytopenic (Ticlid) purpura, are rare but severe.