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paraneoplastic syndrome

Oncology A co-morbid condition due to the indirect–remote or 'biologic' effects of malignancy, which may be the first sign of a neoplasm or its recurrence; PSs occur in > 15% of CAs, are caused by hormones, growth factors, biological response modifiers, and other as-yet unidentified factors, and may regress with treatment of the primary tumor. See Ectopic hormone.
Paraneoplastic syndromes
GI tract, eg anorexia, vomiting, protein-losing enteropathy, liver disease
Hematologic, eg leukemoid reaction, reactive eosinophilia, peripheral 'cytoses or 'cytopenias, hemolysis, DIC, thromboembolism, thrombophlebitis migrans
Hormonal effects
Metabolic disease, eg lactic acidosis, hypertrophic pulmonary osteoarthropathy, hyperamylasemia, hyperlipidemia
Neuromuscular, eg peripheral neuropathy, myopathy, CNS, spinal cord degeneration, inflammation
Renal, eg nephrotic syndrome, uric acid nephropathy
Skin, eg bullous mucocutaneous lesions, acquired ichthyosis, acanthosis nigricans, dermatomyositis
Others, eg callus formation, hypertension, and amyloidosis
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Immune reconstitution for 27 patients receiving NiCord was compared to retrospective cohorts of adolescent and young adults with hematologic malignancies receiving unmanipulated cord blood transplantation (unCBT, n=27) or unrelated bone marrow transplantation (BMT, n=20).
Blacks with pruritus had higher ORs for hematologic and soft tissue malignancies including those of the muscle, fat, and peripheral nerve, investigators said, while whites had higher ORs for skin and liver malignancies.
Amyloidosis of the breast: Predominantly AL type and over half have concurrent breast hematologic disorders.
Clinical characteristics and treatments of patients with hematologic malignancies before or within the 6 months after the diagnosis of hepatitis E are summarized in Table 1 and in the online Technical Appendix Table (http://wwwnc.cdc.gov/ EID/article/21/8/15-0199-Techapp1.pdf).
"This will improve the provision of medical care for children with hematologic deseases in the south.
"To the best of our knowledge, ours is the first study to suggest important gender differences in the association between allergies and hematologic malignancies," says lead author Mazyar Shadman, MD, MPH, a senior fellow in the Clinical Research Division at Seattle's Fred Hutchinson Cancer Research Center.
SL-401 is a novel targeted therapy directed to the interleukin-3 receptor (IL-3R) present on tumor bulk and cancer stem cells (CSCs) of multiple hematologic cancer indications.
Changes may be observed in the hematologic and biochemical parameters depending on the type, intensity and duration of the exercises.
The Phase 3 trial will be conducted across 50 centers in the US, Europe and Australia, and will enroll 240 patients with hematologic malignancies undergoing unrelated bone marrow transplantation using matched or partially mismatched umbilical cord blood.
In malignant hematologic diseases Aeromonastype microorganisms are rarely encountered agents of opportunistic bacterial infection during the neutropenic period following chemotherapy (1).
The drug's label prominently cautions against use for nocturnal cramps and highlights the potential for serious side effects, including thrombocytopenia and other hematologic conditions and cardiac arrhythmias.
The American Society of Hematology (ASH) hosts its seventh state-of-the-art symposium (SAS) on "Recent Advances in Hematologic Malignancies and Platelet Disorders" from Sept.