hematin


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to hematin: haematin, porphyria

hematin

 [he´mah-tin]
1. the hydroxide of heme; it stimulates the synthesis of globin, inhibits the synthesis of porphyrin, and is a component of cytochromes and peroxidases; it is also used as a reagent.
2. hemin (def. 1).

he·ma·tin

(hē'mă-tin, hem'ă-),
Heme in which the iron is Fe(III); the prosthetic group of methemoglobin.

hematin

(hē′mə-tĭn)
n.
A blue to blackish-brown compound, C34H32N4O4·FeOH, formed in the decomposition of hemoglobin.

he·ma·tin

(hē'mă-tin)
Heme in which the iron is Fe(III) (Fe3+); the prosthetic group of methemoglobin.
Synonym(s): ferriheme, hematosin, oxyheme, oxyhemochromogen, haematin.

Hematin

A drug administered intravenously to halt an acute porphyria attack. It causes heme biosynthesis to decrease, preventing the further accumulation of heme precursors.
Mentioned in: Porphyrias
References in periodicals archive ?
B, Formalin fixation alters the structure of heme groups and turns iron into [Fe.sup.3+], generating several intermediate compounds, such as blue-brown hematin, hence, the gray color of formalin-fixed tissues.
Briefly, varying concentrations (0-2 mg/mL in DMSO) of the extracts and fractions were incubated with 3 mM of hematin, 10 mM oleic acid, and 1M HCl.
As an exception, epiquinine and epiquinidine failed to show any effect against Plasmodium falciparum as they lose the aptitude to inhibit p hematin formation.
COX-1 (1 unit/reaction) or COX-2 (0.5 unit/reaction) was added to 180 [micro]L of incubation mixture that consisted of 100 mM tris buffer (pH 8.0), 5 [micro]M porcine hematin, 18 mM L-epinephrine, and 50 pM [Na.sub.2]EDTA.
maltaromaticum involved in accessing iron in myoglobin was examined by evaluating the production of siderophores using a chrome azurol S (CAS) assay, and by examining the ability to bind heme, an iron compound, by growing the culture in a medium containing hematin.
The abdominal pain associated with porphyria can be treated with dextrose infusions, analgesics, and hematin. Long-term management includes monitoring for cirrhosis, iron overload, and possibly, hepatocellular carcinoma.
Hematological studies: The blood samples were analyzed for hemoglobin (Hb) by acid hematin (Sahli's haemoglobinometer) method, Packed Cell Volume (PCV) by microhematocrit, and Total Erythrocyte Count (TEC) and Total Leukocyte Count (TLC) by Neubauer's haemocytometer.
The mean change in menstrual blood loss volume, as quantified using the alkaline hematin method, was -353 mL in the E2V/DNG arm vs.
CO donor Hematin and gaseous CO aqueous solution induced AR in Phaseolus radiatus hypocotyl cuttings.