Coppola et al., "Identification of the hemangioblast
in postnatal life," Blood, vol.
Research by Professor Simon's group demonstrated that EBs with a disrupted HIF1 complex exhibited inappropriate mesodermal and hemangioblast
Xia et al., "Hemangioblastomas share protein expression with embryonal hemangioblast
progenitor cell," Cancer Research, vol.
During development, blood and vascular cells are thought to originate from a progenitor cell known as a hemangioblast
. This research project identified and imposed six transcription factors on the cells that al lowed hemangioblasts
to keep proliferating over multiple generations.
Vereide ct al.; "An Expandable, Inducible Hemangioblast
State Regulated by Fibroblast Growth Factor"; Stem Cell Reports, 2014; DOI: 10.1016/j.
Peng, "Increased hemangioblast
commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice," Development, vol.
patent for its method of generating and expanding hemangioblast
cells from human embryonic stem cells.
Brachyury or T is a member of T-box (TBX) gene family and encodes a transcription factor required in posterior mesoderm formation and axial development along with the development of the hemangioblast
. Initially it appears in the marginal zone of the blastocyst and subsequently restricts its expression into the notochord and the tail bud.
Preclinical data demonstrating hemangioblast
potential of marrow cells and cardioprotective effects of growth factors served as the basis for numerous early phase clinical trials.
Keller, "Development of the hemangioblast
defines the onset of hematopoiesis in human ES cell differentiation cultures," Blood, vol.
Kubo et al., "Tracking mesoderm induction and its specification to the hemangioblast
during embryonic stem cell differentiation," Development, vol.
The new method may overcome these limitations because of a versatile precursor cell called the "hemangioblast