hemangioblast


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hemangioblast

 [he-man´je-o-blast″]
a mesodermal cell that gives rise to both vascular endothelium and hemocytoblasts.

he·man·gi·o·blast

(hē-man'jē-ō-blast),
A primordial embryonic cell of mesodermal origin producing cells from which vascular endothelium, reticuloendothelial elements, and blood-formin are cells of all types are derived.
[hemangio- + G. blastos, germ]

he·man·gi·o·blast

(hē-man'jē-ō-blast)
A primordial embryonic cell of mesodermal origin producing cells from which are derived vascular endothelium, reticuloendothelial elements, and blood-forming cells of all types.
Synonym(s): haemangioblast.
[hemangio- + G. blastos, germ]
References in periodicals archive ?
Coppola et al., "Identification of the hemangioblast in postnatal life," Blood, vol.
Research by Professor Simon's group demonstrated that EBs with a disrupted HIF1 complex exhibited inappropriate mesodermal and hemangioblast differentiation [5].
Xia et al., "Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell," Cancer Research, vol.
During development, blood and vascular cells are thought to originate from a progenitor cell known as a hemangioblast. This research project identified and imposed six transcription factors on the cells that al lowed hemangioblasts to keep proliferating over multiple generations.
Vereide ct al.; "An Expandable, Inducible Hemangioblast State Regulated by Fibroblast Growth Factor"; Stem Cell Reports, 2014; DOI: 10.1016/j.
Peng, "Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice," Development, vol.
patent for its method of generating and expanding hemangioblast cells from human embryonic stem cells.
Brachyury or T is a member of T-box (TBX) gene family and encodes a transcription factor required in posterior mesoderm formation and axial development along with the development of the hemangioblast. Initially it appears in the marginal zone of the blastocyst and subsequently restricts its expression into the notochord and the tail bud.
Preclinical data demonstrating hemangioblast potential of marrow cells and cardioprotective effects of growth factors served as the basis for numerous early phase clinical trials.
Keller, "Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures," Blood, vol.
Kubo et al., "Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell differentiation," Development, vol.
The new method may overcome these limitations because of a versatile precursor cell called the "hemangioblast."