hemagglutination(redirected from hemagglutination inhibition (HI) test)
Also found in: Dictionary, Thesaurus, Encyclopedia.
agglutination of erythrocytes.
hemagglutination inhibition (HI, HAI) test
1. a highly sensitive procedure for the measurement of soluble antigens in biologic specimens; the amount of hemagglutination reflects the amount of free antibody present after reaction with the specimen and thus varies inversely with amount of antigen in the specimen.
2. a procedure for the measurement of serum antibodies directed against a hemagglutinating virus; the highest dilution of serum that completely inhibits hemagglutination by a standardized viral preparation is reported as the hemagglutination titer.
The agglutination of red blood cells; may be immune as a result of specific antibody either for red blood cell antigens themselves or other antigens that coat the red blood cells, or may be nonimmune as in hemagglutination caused by viruses or other microbes.
hemagglutination/he·mag·glu·ti·na·tion/ (he″mah-gloo-tĭ-na´shun) agglutination of erythrocytes.
Etymology: Gk, haima + L, agglutinare, to glue
the agglutination of erythrocytes by an antigen-antibody reaction.
The agglutination of red blood cells; may be immune (as a result of specific antibody to red blood cell antigens or other antigens that coat the red blood cells), or nonimmune (as in hemagglutination caused by viruses or other microbes).
The clumping or clustering of red blood cells caused by certain viruses, antibodies, or other substances.
Mentioned in: Rubella Test
agglutination of erythrocytes usually by either antibodies, viruses or certain plant lectins; abbreviated HA.
indirect hemagglutination test
see hemagglutination inhibition test (below).
hemagglutination inhibition (HI) test
an assay for the presence of specific antiviral antibodies in a test serum. The serum, usually a twofold dilution series, is mixed with a standard number, usually 4 to 8 HA units, of virus and incubated prior to the addition of a standard suspension of erythrocytes. The highest dilution of serum that inhibits hemagglutination is the HI titer of the serum.
passive hemagglutination test
see passive agglutination test.
hemagglutination (HA) test
hemagglutinating viruses directly agglutinate erythrocytes by binding to specific receptor sites on the surface of the erythrocyte and this characteristic can be used in detection, identification and quantitation of the virus.
viruses capable of agglutinating red blood cells of a variety of animals, e.g. adenoviruses, parvoviruses, togaviruses, some coronaviruses, picornaviruses, orthomyxoviruses and paramyxoviruses. Useful in classifying viruses and assaying amounts of virus and antibody. See also hemadsorption.