helicase


Also found in: Dictionary, Encyclopedia, Wikipedia.

helicase

(hel-ĭ-kāz),
A general term describing enzymes capable of unwinding the DNA double helix beginning at the replication fork.
See also: Werner syndrome.

helicase

An enzyme that breaks the hydrogen bonds between the BASE PAIRS in DNA thus separating the two strands of the double helix in the process of replication. Helicase works in conjunction with single-strand binding proteins that attach to the outer side of each single strand preventing the two from rebonding so that two rows of free-ended bases are left as templates on which new complementary strands can be formed.

helicase

an ENZYME that can unwind a NUCLEIC ACID DUPLEX. It disrupts the hydrogen bonds and requires ATP to function.
References in periodicals archive ?
Chromodomain helicase DNA-binding protein 4 (CHD 4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP) inhibitor treatment.
Thompson et al., "The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes," Translational Psychiatry, vol.
Natsukawa et al., "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses," Nature Immunology, vol.
Since the helicase domain I of PVX TGBp1 has been previously reported to be required for in vitro oligomerization [34, 35], amino acid sequences alignment of AltMV TGBp1 and PVX TGBp1 was carried out in search for AltMV TGBp1 oligomerization sites.
A RecB-like helicase in Helicobacter pylori is important for DNA repair and host colonization.
Twinkle helicase (PEO1) gene mutation causes mitochondrial DNA depletion.
The N-terminal domain of NS3 is a serine protease, although its function requires interaction with the NS2B protein as a cofactor, (38-42) whereas the C-terminal domain of NS3 serves as both a helicase, which unwinds double-stranded RNA formed during viral genome replication, and a 5'-RNA triphosphatase, which is involved in formation of the 5' RNA cap.
eIF4E binds to the [m.sup.7]G cap, which then interacts with the multidomain scaffold protein eIF4G and the ATP dependent RNA helicase eIF4A.
Wu Lee, "Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response," Biochemical Journal, vol.
Pascual-Montano et al., 2001 [48], tested their algorithm on rotational power spectra of negative stain images from the G40P helicase of B.
WS is caused by a mutation in the WRN gene, encoding RecQ DNA helicase. The mechanism of premature aging remains unknown, and curative treatment has not been developed.
TDRD9 contains an ATPase/DExH-box ATPase (DExH)type helicase and a Tudor domain and functions in silencing LINE-1 retrotransposon during spermatogenesis.