helicase


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helicase

(hel-ĭ-kāz),
A general term describing enzymes capable of unwinding the DNA double helix beginning at the replication fork.
See also: Werner syndrome.

helicase

An enzyme that breaks the hydrogen bonds between the BASE PAIRS in DNA thus separating the two strands of the double helix in the process of replication. Helicase works in conjunction with single-strand binding proteins that attach to the outer side of each single strand preventing the two from rebonding so that two rows of free-ended bases are left as templates on which new complementary strands can be formed.

helicase

an ENZYME that can unwind a NUCLEIC ACID DUPLEX. It disrupts the hydrogen bonds and requires ATP to function.
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References in periodicals archive ?
Chromodomain helicase DNA-binding protein 4 (CHD 4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP) inhibitor treatment.
Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel independent prognostic biomarker for colorectal cancer
Thompson et al., "The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes," Translational Psychiatry, vol.
Whole-Exome Sequencing Identifies One De Novo Variant in the FGD6 Gene in a Thai Family with Autism Spectrum Disorder
Natsukawa et al., "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses," Nature Immunology, vol.
Viruses Seen by Our Cells: The Role of Viral RNA Sensors
Since the helicase domain I of PVX TGBp1 has been previously reported to be required for in vitro oligomerization [34, 35], amino acid sequences alignment of AltMV TGBp1 and PVX TGBp1 was carried out in search for AltMV TGBp1 oligomerization sites.
Alternanthera mosaic potexvirus: Several Features, Properties, and Application
A RecB-like helicase in Helicobacter pylori is important for DNA repair and host colonization.
Detection and Genotyping of Helicobacter pylori among Gastric ulcer and Cancer Patients from Saudi Arabia
Twinkle helicase (PEO1) gene mutation causes mitochondrial DNA depletion.
GEN-011: Sindrome de deplecion de ADN mitocondrial 7 (tipo hepatocerebral)
The N-terminal domain of NS3 is a serine protease, although its function requires interaction with the NS2B protein as a cofactor, (38-42) whereas the C-terminal domain of NS3 serves as both a helicase, which unwinds double-stranded RNA formed during viral genome replication, and a 5'-RNA triphosphatase, which is involved in formation of the 5' RNA cap.
Zika Virus: The Agent and Its Biology, With Relevance to Pathology
eIF4E binds to the [m.sup.7]G cap, which then interacts with the multidomain scaffold protein eIF4G and the ATP dependent RNA helicase eIF4A.
Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression
Wu Lee, "Critical roles of RNA helicase DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response," Biochemical Journal, vol.
Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases
Pascual-Montano et al., 2001 [48], tested their algorithm on rotational power spectra of negative stain images from the G40P helicase of B.
Structural Study of Heterogeneous Biological Samples by Cryoelectron Microscopy and Image Processing
WS is caused by a mutation in the WRN gene, encoding RecQ DNA helicase. The mechanism of premature aging remains unknown, and curative treatment has not been developed.
The Relationship between Werner Syndrome and Sinonasal Malignant Melanoma: Two Sibling Cases of Werner Syndrome with Malignant Melanoma
TDRD9 contains an ATPase/DExH-box ATPase (DExH)type helicase and a Tudor domain and functions in silencing LINE-1 retrotransposon during spermatogenesis.
Tudor domain containing protein TDRD12 expresses at the acrosome of spermatids in mouse testis

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