DNA-binding protein 4 (CHD 4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly (ADP-ribose) polymerase (PARP) inhibitor treatment.
Thompson et al., "The autism-associated gene chromodomain helicase
DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes," Translational Psychiatry, vol.
Natsukawa et al., "The RNA helicase
RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses," Nature Immunology, vol.
Since the helicase
domain I of PVX TGBp1 has been previously reported to be required for in vitro oligomerization [34, 35], amino acid sequences alignment of AltMV TGBp1 and PVX TGBp1 was carried out in search for AltMV TGBp1 oligomerization sites.
A RecB-like helicase
in Helicobacter pylori is important for DNA repair and host colonization.
(PEO1) gene mutation causes mitochondrial DNA depletion.
The N-terminal domain of NS3 is a serine protease, although its function requires interaction with the NS2B protein as a cofactor, (38-42) whereas the C-terminal domain of NS3 serves as both a helicase
, which unwinds double-stranded RNA formed during viral genome replication, and a 5'-RNA triphosphatase, which is involved in formation of the 5' RNA cap.
eIF4E binds to the [m.sup.7]G cap, which then interacts with the multidomain scaffold protein eIF4G and the ATP dependent RNA helicase
Wu Lee, "Critical roles of RNA helicase
DDX3 and its interactions with eIF4E/PABP1 in stress granule assembly and stress response," Biochemical Journal, vol.
Pascual-Montano et al., 2001 , tested their algorithm on rotational power spectra of negative stain images from the G40P helicase
WS is caused by a mutation in the WRN gene, encoding RecQ DNA helicase
. The mechanism of premature aging remains unknown, and curative treatment has not been developed.
TDRD9 contains an ATPase/DExH-box ATPase (DExH)type helicase
and a Tudor domain and functions in silencing LINE-1 retrotransposon during spermatogenesis.