The primary endpoint of the trial is height velocity
at 52 weeks.
The authors estimated age at the peak height velocity
(PHV), maximum growth velocity during puberty, and childhood body mass index (BMI) at age 8 years for all study participants.
Several studies (Georgopoulos et al., 2002; Thomis et al., 2005; Beunen & Malina, 2007; Avila-Carvalho et al., 2013; Malina et al., 2013; Purenovic-Ivanovic et al., 2017) indicate that gymnasts have a late in pubertal stages, age at menarche and age at peak height velocity
(PHV), especially in elite gymnasts.
Before the treatment, mean annual height velocity
of the patients was 3.96[+ or -]0.83 cm, height standard deviation (SD) score (SDS) was -3.86[+ or -]0.75, bone age was 4.84[+ or -]2.97 years, upper segment/lower segment ratio was 1.34[+ or -]0.2, and specific radiographic findings were present in all cases (Table 1).
The peak height velocity
(PHV) is the period whereby an individual experiences their greatest rate of growth and maturation, hence it serves as a vital time point for referencing physical fitness gains (5, 6).
Inclusion criteria were as follows: (1) diagnosis of SGA (Birth weight and/or length < -2 SDS), (2) treatment with recombinant human GH (rGH), given continuously on a daily basis during at least 3 years when treatment started before puberty and at least 2 years when started near the onset of puberty, (3) breast stage <B3 for girls and a testicular volume < 10 ml for boys at the start of GH therapy, and (4) achievement of AH, defined as a height velocity
< 2 cm/year.
To control for possible confounding effects of maturation, age from peak height velocity
(PHV) and the maturity offset as chronological age were calculated from chronological age, body height, sitting height and body mass according to Mirwald et al.
Adopting this procedure allowed researchers to calculate peak height velocity
(PHV) in a transversal manner.
A number of previous studies indicate that the height velocity
in the new born adjusts toward the genetically predicted pathways (Veldhuis et al., 2005).
Peak Height Velocity
. To establish the age at peak linear growth (indexed as peak height velocity
(PHV)) for each child, whole-year height velocity
values were calculated for each participant using childhood and adolescent data by dividing the difference between the annual distance increments by the age increment.
We therefore added an analysis, comparing whether height velocity
in patients with duration of 3-12 months differs from those with a duration exceeding 12 months and found no significant difference in height velocity
between the groups.
Physical growth of normal German children from birth to 18 years--longitudinal study of height, weight, height velocity
. Klin Padiatr.