To control for possible confounding effects of maturation, age from peak height velocity
(PHV) and the maturity offset as chronological age were calculated from chronological age, body height, sitting height and body mass according to Mirwald et al.
A number of previous studies indicate that the height velocity
in the new born adjusts toward the genetically predicted pathways (Veldhuis et al.
Physical growth of normal German children from birth to 18 years--longitudinal study of height, weight, height velocity
The primary endpoint is non-inferiority between the two treatment groups for 12 month height velocity
Malina and Bouchard (20) suggested that the reduction in the rate of increase in HT at approximately 15 yrs of age corresponds to the peak height velocity
A "typical" clinical picture of the GH1 in a child includes severe proportional short stature, decreased height velocity
, delayed bone age, delayed puberty, a high-pitched voice and overcrowded teeth.
The second stage (Phase 2a) will further study these patients to determine the efficacy of VRS-317 as defined by an increase in height velocity
over six months of treatment.
Longitudinal associations of serum OCPs with annual measurements of body mass index (BMI), height and height velocity
were examined by multivariate mixed-effects regression models for repeated measures, controlling for potential confounders.
4 shows a height velocity
chart for boys, published by Tanner and Davies.
Among the 57 patients on whom there was complete growth data, the mean height velocity
z score increased from -1.
A biological maturational age was determined by estimating attainment of age at peak height velocity
At 9 months, height velocity
was similar for both, with a mean of 10.