are a class of novel human proteins that are responsible for inducing the formation or regeneration of tissues.
These data suggest that Hedgehog antagonists may have therapeutic value not just in cancers driven by mutations in the Hedgehog signaling pathway, such as basal cell carcinomas (BCC), but also potentially in cancers where Hedgehog signaling is driven by overexpression of the Hedgehog protein
," said Dan Passeri, Curis' President and CEO.
We and Wyeth have also made strides on the preclinical development of a systemically administered Hedgehog protein
drug candidate for cardiovascular applications and I look forward to further updates on both of these programs in the future.
Cautionary Statement: This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding Curis' plans to immediately begin contacting potentially interested parties for licensure of its BMP-7 program; its plans to continue to progress a number of its other programs including CUDC-101, other multi-target inhibitors, a Hedgehog antagonist for cancer, Hedgehog agonists for stroke, and Hedgehog protein
for cardiovascular disease; and Curis' plans to continue to seek a collaborator for CUDC-101.
He has since become one of the foremost experts Co along with Stanford's Matthew Scott, PhD, professor of developmental biology Co in understanding how the Hedgehog protein
signals cells during the fetal development of such animals as flies, mice and humans.
The claims of this patent recite methods of producing Hedgehog protein
in a baculovirus expression system during fermentation and have broad application for Curis' Hedgehog pathway programs.
from the Regenerative BioScience Center at the University of Georgia, grew NIH-approved human embryonic stem cells in culture and induced them to differentiate into motor neuron cells by adding basic fibroblast growth factor, sonic hedgehog protein
, and retinoic acid to the culture medium.
Elizabeth's Medical Center in Boston reported that injection of a gene encoding a Hedgehog protein
in preclinical models of heart disease resulted in improved cardiac function and increased blood flow to the heart in both acute and chronic models of myocardial ischemia.
NASDAQ: CRIS) today announced that a paper will be presented on Tuesday, November 11, 2003, demonstrating that injection of a gene encoding the Hedgehog protein
results in improved cardiac function and increased blood flow to the heart in a model of myocardial ischemia.
NASDAQ: CRIS) today announced that there will be a presentation of a paper on Friday, October 24, 2003 at the annual meeting of the North American Spine Society which demonstrates that administration of Hedgehog protein
and certain brain precursor cells results in improved function in a model of spinal cord injury.
Treating blind fish embryos with a drug that inhibits both the hedgehog proteins
partially restored eye development.