hedgehog protein


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hedgehog protein

a family of secreted intercellular signaling proteins that plays an essential role in early embryonic patterning of major organs, including the brain, eye, bone, gonads, skin, blood, gastrointestinal tract, lungs, and prostate. In mammals, three hedgehog proteins have been identified: sonic hedgehog, indian hedgehog, and desert hedgehog. Two receptors for hedgehog proteins have been identified: patched (Ptc), a negative regulator of Hh-signaling pathways, and smooth-end (Smo), a positive regulator. Abnormal functioning of the signaling pathway has been implicated in many forms of birth defects. In postembryonic life, the pathway may be activated to stimulate tissue repair or cell proliferation. Abnormal activation may lead to cancer, including basal cell carcinoma, the most common form of human cancer.
Any of a class of signalling molecules that are critical to development in vertebrate embryology
References in periodicals archive ?
In the paracrine setting, the Hedgehog protein is expressed by the tumor cells but has its biologic effect upon the surrounding supporting cells (stromal cells), including effecting these surrounding cells to support growth of the Hedgehog-secreting tumor cells.
Cautionary Statement: This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding Curis' plans to immediately begin contacting potentially interested parties for licensure of its BMP-7 program; its plans to continue to progress a number of its other programs including CUDC-101, other multi-target inhibitors, a Hedgehog antagonist for cancer, Hedgehog agonists for stroke, and Hedgehog protein for cardiovascular disease; and Curis' plans to continue to seek a collaborator for CUDC-101.
As that work progressed during his 18-year career at Johns Hopkins, Beachy realized that the Hedgehog protein signaling pathway also had a role in cancer.
Lee Rubin, Curis' Chief Scientific Officer, said, "Previous studies have demonstrated that Hedgehog protein can stimulate formation of new blood vessels and promote the recovery of skeletal muscle that has an insufficient blood supply.
Treating blind fish embryos with a drug that inhibits both the hedgehog proteins partially restored eye development.
In January 2004, Curis licensed its Hedgehog proteins and small molecule Hedgehog pathway agonists to Wyeth for therapeutic applications in the treatment of neurological diseases and other disorders.
In January 2004, Curis licensed its Hedgehog proteins and novel small molecule Hedgehog pathway agonists to Wyeth for therapeutic applications in the treatment of neurological and other disorders.
NASDAQ:CRIS) has licensed its Hedgehog proteins and novel small molecule Hedgehog pathway agonists (activators) to Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), for therapeutic applications in the treatment of neurological and other disorders.