hedgehog protein


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hedgehog protein

a family of secreted intercellular signaling proteins that plays an essential role in early embryonic patterning of major organs, including the brain, eye, bone, gonads, skin, blood, gastrointestinal tract, lungs, and prostate. In mammals, three hedgehog proteins have been identified: sonic hedgehog, indian hedgehog, and desert hedgehog. Two receptors for hedgehog proteins have been identified: patched (Ptc), a negative regulator of Hh-signaling pathways, and smooth-end (Smo), a positive regulator. Abnormal functioning of the signaling pathway has been implicated in many forms of birth defects. In postembryonic life, the pathway may be activated to stimulate tissue repair or cell proliferation. Abnormal activation may lead to cancer, including basal cell carcinoma, the most common form of human cancer.
Any of a class of signalling molecules that are critical to development in vertebrate embryology
References in periodicals archive ?
Hedgehog proteins are a class of novel human proteins that are responsible for inducing the formation or regeneration of tissues.
These data suggest that Hedgehog antagonists may have therapeutic value not just in cancers driven by mutations in the Hedgehog signaling pathway, such as basal cell carcinomas (BCC), but also potentially in cancers where Hedgehog signaling is driven by overexpression of the Hedgehog protein," said Dan Passeri, Curis' President and CEO.
We and Wyeth have also made strides on the preclinical development of a systemically administered Hedgehog protein drug candidate for cardiovascular applications and I look forward to further updates on both of these programs in the future.
Cautionary Statement: This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding Curis' plans to immediately begin contacting potentially interested parties for licensure of its BMP-7 program; its plans to continue to progress a number of its other programs including CUDC-101, other multi-target inhibitors, a Hedgehog antagonist for cancer, Hedgehog agonists for stroke, and Hedgehog protein for cardiovascular disease; and Curis' plans to continue to seek a collaborator for CUDC-101.
He has since become one of the foremost experts Co along with Stanford's Matthew Scott, PhD, professor of developmental biology Co in understanding how the Hedgehog protein signals cells during the fetal development of such animals as flies, mice and humans.
The claims of this patent recite methods of producing Hedgehog protein in a baculovirus expression system during fermentation and have broad application for Curis' Hedgehog pathway programs.
from the Regenerative BioScience Center at the University of Georgia, grew NIH-approved human embryonic stem cells in culture and induced them to differentiate into motor neuron cells by adding basic fibroblast growth factor, sonic hedgehog protein, and retinoic acid to the culture medium.
Elizabeth's Medical Center in Boston reported that injection of a gene encoding a Hedgehog protein in preclinical models of heart disease resulted in improved cardiac function and increased blood flow to the heart in both acute and chronic models of myocardial ischemia.
NASDAQ: CRIS) today announced that a paper will be presented on Tuesday, November 11, 2003, demonstrating that injection of a gene encoding the Hedgehog protein results in improved cardiac function and increased blood flow to the heart in a model of myocardial ischemia.
NASDAQ: CRIS) today announced that there will be a presentation of a paper on Friday, October 24, 2003 at the annual meeting of the North American Spine Society which demonstrates that administration of Hedgehog protein and certain brain precursor cells results in improved function in a model of spinal cord injury.
Treating blind fish embryos with a drug that inhibits both the hedgehog proteins partially restored eye development.