heavy guns

Oncology Referring to the use of aggressive chemotherapy, as in, ‘We’re going to hit Mr. Smith’s metastatic melanoma with heavy guns’—i.e., with multiple agents and/or therapeutic modalities
Vox populi Formidable, serious

heavy guns

adjective Formidable, serious Oncology Referring to the use of aggressive chemotherapy in advanced malignancy, which is hit with HGs–eg, multiple agents and therapeutic modalities. See Induction.
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References in classic literature ?
By this time we were well used to the roar of heavy guns, the rattle of musket fire, and the flying of shot near us; but never had I been under such a fire as we rode through on that day.
And as he watched, so did he listen, though he rode on in silence, save for the boom of heavy guns from far to the west.
Stripping his harness from him I securely bound his hands behind his back, and after similarly fastening his feet tied him to a heavy gun carriage.
They were mounted upon rough adaptations of the Doan swivel, which at that time gave the maximum vertical range to a heavy gun. Much of this artillery was still unmounted, and nearly all of it was unprotected when the German air-fleet reached New York.
The transportation of a single heavy gun was often considered equal to a victory gained; if happily, the difficulties of the passage had not so far separated it from its necessary concomitant, the ammunition, as to render it no more than a useless tube of unwieldy iron.
A video released by the Libyan National Army (LNA) media office showed a convoy of armored vehicles and pickup trucks mounted with heavy guns on the road.
class="MsoNormalGen Muntu said Ugandans should use their mind to fight those in power who wield heavy guns like tankers and rocket propelled grenades to threaten them.
The army men further destroyed two military vehicles of the terrorists, equipped with heavy guns, in al-Hawi and Khirbet al-Hawi regions towards Tal Qanem.
They fired rockets on some houses of Bijaranis besides using heavy guns, he added.
We were led to believe rock giants Metallica were bringing out the heavy guns against the parasites who are squeezing the life out of live events.
The source told the National Iraqi News Agency / NINA / Turkish heavy guns pounded Shalalat and Fadiliyah areas, killing about a dozen of Daash militants and knocked four vehicles of the organization.
The long-awaited onslaught on the city of Fallujah, just 30 miles west of Baghdad, opened at 4am yesterday with the heavy guns of the Iraqi army blasting IS fanatics dug in on the outskirts.