heavy guns

Oncology Referring to the use of aggressive chemotherapy, as in, ‘We’re going to hit Mr. Smith’s metastatic melanoma with heavy guns’—i.e., with multiple agents and/or therapeutic modalities
Vox populi Formidable, serious

heavy guns

adjective Formidable, serious Oncology Referring to the use of aggressive chemotherapy in advanced malignancy, which is hit with HGs–eg, multiple agents and therapeutic modalities. See Induction.
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References in classic literature ?
By this time we were well used to the roar of heavy guns, the rattle of musket fire, and the flying of shot near us; but never had I been under such a fire as we rode through on that day.
And as he watched, so did he listen, though he rode on in silence, save for the boom of heavy guns from far to the west.
Stripping his harness from him I securely bound his hands behind his back, and after similarly fastening his feet tied him to a heavy gun carriage.
They were mounted upon rough adaptations of the Doan swivel, which at that time gave the maximum vertical range to a heavy gun.
The transportation of a single heavy gun was often considered equal to a victory gained; if happily, the difficulties of the passage had not so far separated it from its necessary concomitant, the ammunition, as to render it no more than a useless tube of unwieldy iron.
We were led to believe rock giants Metallica were bringing out the heavy guns against the parasites who are squeezing the life out of live events.
The source told the National Iraqi News Agency / NINA / Turkish heavy guns pounded Shalalat and Fadiliyah areas, killing about a dozen of Daash militants and knocked four vehicles of the organization.
The long-awaited onslaught on the city of Fallujah, just 30 miles west of Baghdad, opened at 4am yesterday with the heavy guns of the Iraqi army blasting IS fanatics dug in on the outskirts.
The Syrian Army's general command also said in a statement that "more than 400 terrorists, supported by armored vehicles, artillery and equipped with mortars and other sophisticated heavy guns, have participated in the attacks to break the army's fortifications or cutting off Aleppo-Afrin road, however the offensive was conducted to no avail, other than more casualties which were inflicted on the terrorists".
Freddie Roach is ready to bring out the heavy guns as he prepares Manny Pacquiao for his farewell fight.
While the drill might appear simple to those who are using heavy guns with light triggers and long slides, try the drill with the gun you're most likely to be carrying: a pocket pistol or a large-caliber compact pistol from an inside-the-waistband holster.
Complementing the music will be the thrills of the exciting displays including the RMRNC Inter-Service Field Gun Competition, featuring the Royal Navy, Army and RAF, which will prove how both Gun Competition at the military sheer strength and agility are needed to control the heavy guns as they race each other.