heavy chain


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Related to heavy chain: light chain, heavy chain disease

chain

 [chān]
a collection of objects linked together in linear fashion, or end to end, as the assemblage of atoms or radicals in a chemical compound, or an assemblage of individual bacterial cells.
branched chain an open chain of atoms, usually carbon, with one or more side chains attached to it.
closed chain several atoms linked together so as to form a ring, which may be saturated, as in cyclopentane, or aromatic, as in benzene.
H chain (heavy chain) any of the large polypeptide chains of five classes that, paired with the L or light chains, make up the antibody molecule of an immunoglobulin; heavy chains bear the antigenic determinants that differentiate the classes of immunoglobulins. See also heavy chain disease.
J chain a polypeptide occurring in polymeric IgM and IgA molecules.
L chain (light chain) either of the two small polypeptide chains (molecular weight 22,000) that, when linked to H or heavy chains by disulfide bonds, make up the antibody molecule of an immunoglobulin monomer; they are of two types, kappa and lambda, which are unrelated to immunoglobulin class differences.
open chain a series of atoms united in a straight line; components of this series are related to methane.
chain reaction a chemical reaction that is self-propagating; each time a free radical is destroyed a new one is formed.
side chain a group of atoms attached to a larger chain or to a ring.

heav·y chain

a polypeptide chain a subunit of an immunoglobulin molecule, of high molecular weight, such as the γ, α, μ, δ, or ε chains, determining the immunoglobulin class and subclass. This chain also determines whether complement can be bound and whether the chain can pass through the placenta. There are two identical chains in each immunoglobulin.
Synonym(s): H chain

heavy chain

n.
The larger of the two types of polypeptide chains in immunoglobulins, consisting of an antigen-binding portion having a variable amino acid sequence, and a constant region that defines the antibody class.

heav·y chain

(hev'ē chān)
A polypeptide chain of high molecular weight determining the class and subclass of an immunoglobulin.

heavy chain

see IMMUNOGLOBULIN.
References in periodicals archive ?
Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis.
Moreover, the purified ferret Ig preparation had the potential to elicit mAb with specificity for the heavy chain (Ig[mu] or Ig[gamma]) and the light chain (Ig[kappa] or Ig[lambda]) using a single antigen.
Cases of heavy-chain disease may involve [gamma], [alpha], or [mu] heavy chains. When an abnormal monoclonal band is identified, it is usually a broad band found in the [alpha]-2 or [beta]-globulin region.
The levels of mRNAs for UPR markers, including Grp78, CHOP, and XBP-1 transcription factor, were significantly increased in bone marrow-derived macrophages, where accumulation of misfolded heavy chain induced by HLA-B*27 upregulation highly correlated with the magnitude of the UPR.
Dammacco, "[[beta].sub.2]-microglobulin-free HLA class I heavy chain epitope mimicry by monoclonal antibody HC-10-specific peptide," The Journal of Immunology, vol.
Caption: Figure 5: Percentage of the main myofibrillar proteins from beef, lamb, and chicken samples extracted with denaturing and nondenaturing solutions (D = denaturing; ND = nondenaturing; MHC = myosin heavy chain; a-act = [alpha]-actinin; TnT = troponin T; TPM = tropomyosin; MLC1 = myosin light chain 1; MLC2 = myosin light chain 2; *P < 0.05; **P < 0.01; ***P < 0.001) (means [+ or -] SEM).
The amounts of free light chain (LC), free heavy chain (HC), HL, HH, and HHL of HS628 and originator tocilizumab were comparable, and the average percentage of mAb (monomer) was 95.3% for HS628 (n = 4) and 95.0% for originator tocilizumab (n = 4) (Figure 7(a)).
Although the use of two separate vectors for the expression of heavy chain and light chain has been reported, this approach has serious shortcomings such as the possibility of the integration of the two vectors in different genomic sites and the variation of the copy number for each gene which can in turn cause an improper ratio of the expressed light chain to heavy chain, and reduce the possibility of achieving cell clones with high expression level of active antibody.
Myosin heavy chain mRNA transform to faster isoforms in immobilized skeletal muscle: A quantitative PCR study.
Mass analysis of Grp94-positive heavy chain did not permit identifying the site in IgG specifically involved in binding Gp94, since tryptic digestion of the heavy chain yielded peptides that always matched those of control IgG heavy chain (data not shown).
The secondary FITC-conjugated anti-mouse antibody (Sigma) at 1:100 dilution for anti a actinin, myosin heavy chain, and cardiac troponin T and FITC-conjugated donkey anti-rabbit antibody (Santa Cruz) for atrial natriuretic peptide with the same dilution were used.