heat-shock proteins


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Related to heat-shock proteins: heat shock response

heat-shock proteins

A range of peptides that are well conserved throughout a wide range of organisms and are produced by the body in response to various stressors. They are found in high concentration in plaques of ATHEROSCLEROSIS and levels of heat-shock proteins in people who have suffered strokes and heart attacks, and women with breast cancer, are higher than in controls. Antibodies against bacterial HSP can cross-react with human HSP60 causing cytotoxic damage to endothelial cells stressed by FREE RADICALS or infection. Heat-shock proteins are also associated with oral ulcers and Behçet's disease. They are found in a variety of bacteria.
References in periodicals archive ?
The comprehensive study of heat-shock proteins is of great importance to both livestock and aquaculture.
Molecular chaperone functions of heat-shock proteins. Annu.
The age-related decline in heat-shock proteins--notably heat-shock protein 70 (HSP70)--diminishes the skin's natural stress response and accelerates aging.
Molecular cloning and characterization of cDNA encoding a putative stress-induced heat-shock protein from Camelus dromedarius.
Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma.
Variation in the expression of Hsp70, the major heat-shock protein, and thermotolerance in larval and adult selection lines of Drosophila melanogaster.
Engman, "Human antibody responses to Trypanosoma cruzi 70-kD heat-shock proteins," American Journal of Tropical Medicine and Hygiene, vol.
Some like it hot: the structure and function of small heat-shock proteins. Nat Struct Mol Biol.
"Although heat-shock proteins act as protective chaperones," Dr.
The heatshock response: regulation and function of heat-shock proteins and molecular chaperones.
Genomewide transcript analyses of lungs from air- and [O.sub.3] -exposed HeJ and OuJ mice identified a cluster of genes that were significantly up-regulated in Oj-exposed OuJ mice compared with [O.sub.3] -exposed HeJ mice or air-exposed controls of both strains; this cluster included genes for heat-shock proteins (e.g., Hspalb, Hsp70).