DUSP8

(redirected from hb5)
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DUSP8

A gene on chromosome 11p15.5 that encodes dual-specificity phosphatase 8, a protein which is induced by nerve growth factor and insulin, inactivates SAPK/JNK and p38, and is expressed predominantly in the adult brain, heart and skeletal muscle.
References in periodicals archive ?
The 5' thiol-modified aptamer HB5 was first activated and then conjugated to the maleimide group at the N terminus of substrate peptide by Michael addition to form a thiol--maleimide linkage (20).
For example, the [beta]-globin E6V mutation, which leads to hemoglobin S (Hb5), the most common abnormal Hb that was selected in many populations because of the protection it brings in the heterozygous state against malaria, is returned as benign by PolyPhen.
The data show that individuals 1, 2, and 3 were homozygous for both HbA and non-E; individuals 4, 5, and 6 were HbA/5 heterozygotes and homozygous for non-E; individuals 7, 8, and 9 were homozygous for both Hb5 and non-E; and individuals 10, 11, and 12 were HbA homozygotes and non-E/HbE heterozygotes.