Herrera, Vasorelaxant effects of harmine and harmaline
extracted from Peganumharmala L.
We recently reported that administration of a single oral dose of ayahuasca (dose: 2.2 mL/kg; alkaloid content in the sample: 0.8 mg/mL DMT, 0.21 mg/mL harmine, no harmaline
was detected, and THH was not analyzed due to a lack of analytical requirements) in an open-label trial to 17 patients with treatment-resistant major depressive disorder (MDD) was associated with significant decreases in depression symptoms assessed with the Hamilton Rating Scale for Depression (HAM-D) and the Montgomery-Asberg Depression Rating Scale (MADRS) from 80 minutes to day 21 (10,11).
In the aromatic region, vasicine, vasicinone, harmaline
, and harmine were identified in the methanol extracts of P.
is a methoxyharmalol and a dihydroharmine; it constitutes 2/3 of the total alkaloids of the seed; it would be twice as toxic as the harmine (Figure 5) .
Harmine, tetrahydroharmine and harmaline
are potent inhibitors of peripheral type-A monoamine oxidase (MAO-A).
harmala are rich in /S-carboline alkaloids harmine, harmane, and harmaline
which showed to possess hallucinogenic effects (Araujo et al., 2015; Cheng et al., 2010) and are lacking in quinazoline alkaloids, namely, VAS, DVAS, and VAO.
Kurucu, "HPLC method for the analysis of harmol, harmalol, harmine and harmaline
in the seeds of Peganum harmala L.," Journal of Pharmaceutical and Biomedical Analysis, vol.
Harmala seeds contain compounds such as Alkaloids like Harmaline
, Harmaine, Harmalole, Harman, Vasicine and Vasizinone .
harmala extracts were identified as tetrahydroharmine, harmalol, harmine, harmol and harmaline
(Herraiz et al., 2010).
Vasicine has the structure of quinazoline; harmaline
(2.1%), harmine (1.6%); and harmalol became tryptamine.
caapi mixed with tobacco leaves, which is consistent with the chemical analysis of the ayahuasca brew that found harmine, harmaline
, and nicotine.
, harmine, harmalol and harmol are the main beta carboline alkaloids in Peganum harmala extracts.