haptoglobin


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haptoglobin

 [hap´to-glo″bin]
a group of serum alpha2-globulin glycoproteins that bind free hemoglobin; three phenotypes, with differing abilities to bind hemoglobin, are distinguished electrophoretically.

hap·to·glo·bin (HP),

(hap'tō-glō'bin), [MIM*140100 & MIM*140210]
A group of α2-globulins in human serum, so called because of their ability to combine with hemoglobin, preventing loss in the urine; variant types form a polymorphic system, with α- and β-polypeptide chains controlled by separate genetic loci. Levels are decreased in hemolytic disorders and increased in inflammatory conditions or with tissue damage.
[G. haptō, to grasp, + hemoglobin]

haptoglobin

(hăp′tə-glō′bĭn)
n.
A plasma protein that is a normal constituent of blood serum and functions in the binding of free hemoglobin in the bloodstream.

haptoglobin

A protein in the circulation that migrates in the α2 portion of serum subjected to electrophoresis, a so-called acute phase reactant that ↑ in serum in acute inflammation or infection, stress, or necrosis Role Bind Hb released from RBCs undergoing hemolysis, preventing the accumulation of Hb in plasma; after iron has been removed, the haptoglobin-bound Hb is eliminated by the reticuloendothelial system.

hap·to·glo·bin

(hap'tō-glō'bin)
A group of α2-globulins in human serum, so called because of their ability to combine with hemoglobin; variant types form a polymorphic system, with α- and β-polypeptide chains controlled by separate genetic loci.
[G. haptō, to grasp, + hemoglobin]

haptoglobin

Alpha2 -globulin, a plasma protein that binds free haemoglobin to form a complex too large to pass out of the kidneys into the urine.

Haptoglobin

A blood protein made by the liver. Its main role is to save iron by attaching itself to any hemoglobin released from a red cell.
References in periodicals archive ?
The HOPE and WHS studies "had previously both shown no overall benefit from vitamin E" compared with placebo when the analysis included all participants, regardless of their diabetes status and haptoglobin genotype status.
LDH 442 U/L 327 U/L Haptoglobin Less than 8 mg/dL 107 mg/dL Fibrinogen level 616 mg/dL 369 mg/dL Reticulocytes 190 K/[micro]L 80 K/[micro]L BUN 28 mg/dL 11 mg/dL Creatinine 3.3 mg/dL 1.0 mg/dL Calcium 13.68 mg/dL 7.5 mg/dL ALP 300 U/L 109 U/L AST 215 U/L 21 U/L ALT 171 U/L 25 U/L Schistocytes Present Absent Burr cells Marked Absent
That was suggested by the decrease of transferrin and haptoglobin concentrations observed in [NAT.sub.2000], and by the negative relationship found between race duration and transferrin concentrations in [NAT.sub.2000].
If any haptoglobin - such as in a blood sample from a cow - comes in contact with the Hap 1 antibody, it will bind tightly to the antibody.
Inf EP Basal MLI Lucigenin 1/10 dilution IgM 0.37 0.032 Haptoglobin 0.52 0.003 [Alpha]-1AG 0.37 0.030 Prealbumin -0.35 0.046
Haptoglobin usually increases 2- to 10-fold and is especially high in FIP (TIZARD, 2013b).
The prevalence of CKD stages 3-5 in Iran is 14.9%.1 Anaemia is a common complication of CKD2 which may be due to lack of erythropoietin, low folic acid, vitamin B12 and iron levels.3 It has been shown that correction of anaemia is associated with improved outcomes in CKD patients.4 In patients with CKD, anaemia can be treated using recombinant human erythropoietin, but some of these patients develop resistance to erythropoietin.5 In CKD, chronic inflammation plays an important role in the disease process.6 It has been reported that the resistance to erythropoietin treatment is one of the important outcomes of chronic inflammation in CKD.7 Several proteins such as haptoglobin (HP) are produced from hepatocytes during chronic inflammation in CKD.
Dr Catalin Buhimschi and Dr Irina Buhimschi led the research and analysed cord blood samples from 921 newborns to see if haptoglobin was associated with poor outcomes in babies who had been exposed to in-utero inflammation, which causes about 30 per cent of preterm births.
Influence of clinical factors on the haemolysis marker haptoglobin. Eur J Clin Invest 2006 Mar;36(3):202-209.
All hematological Parameters were given with reference range Hemotological Parameters Value Reference range Hemoglobin (g/dL) 1,2 14-18 Hematocrit (%) 7,7 42-52 Red Blood Cells (u/L) 1,25 4-6,13 White Blood Cells (u/L) 7,23 4,3-10,3 Mean corpuscular volume (fL) 60 80-97 Mean corpuscular hemoglobin (pg) 9,3 25-33,3 Mean corpuscular hemoglobin concentration (g/dL) 15,8 30-35 Total iron binding capacity ([micro]g/dL) 499 241-421 Transferrin saturation (%) 0,1 18%-48% Transferrin (mg/dL) 249 180-344 Blood Iron ([micro]g/dL) 17 30-162 Haptoglobin (mg/dL) 193 62-197 Folat (pg/mL) 11 2,5-20 Vitamin B12 (nmol/L) 180 180-914
Besides, to indicate parameter for inflammatory response, serum haptoglobin was measured in five periods, on day 1, 21, 42, 63, and 105 during feedlot.
Infected quail had higher plasma levels of ceruloplasmin, unsaturated iron-binding capacity (UIBC), iron, and total iron-binding capacity (TIBC), and lower levels of haptoglobin, compared to uninfected controls.