haptoglobin


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haptoglobin

 [hap´to-glo″bin]
a group of serum alpha2-globulin glycoproteins that bind free hemoglobin; three phenotypes, with differing abilities to bind hemoglobin, are distinguished electrophoretically.

hap·to·glo·bin (HP),

(hap'tō-glō'bin), [MIM*140100 & MIM*140210]
A group of α2-globulins in human serum, so called because of their ability to combine with hemoglobin, preventing loss in the urine; variant types form a polymorphic system, with α- and β-polypeptide chains controlled by separate genetic loci. Levels are decreased in hemolytic disorders and increased in inflammatory conditions or with tissue damage.
[G. haptō, to grasp, + hemoglobin]

haptoglobin

/hap·to·glo·bin/ (hap″to-glo´bin) a plasma glycoprotein with alpha electrophoretic mobility that irreversibly binds free hemoglobin, resulting in removal of the complex by the liver and preventing free hemoglobin from being lost in the urine; it has two major genetic variants, Hp 1 and Hp 2.

haptoglobin

(hăp′tə-glō′bĭn)
n.
A plasma protein that is a normal constituent of blood serum and functions in the binding of free hemoglobin in the bloodstream.

haptoglobin

[hap′tōglō′bin]
Etymology: Gk, haptein, to grasp; L, globus, ball
a plasma protein that irreversibly binds free hemoglobin and is removed by macrophages conserving iron. The quantity of haptoglobin is increased in certain chronic diseases and inflammatory disorders and is decreased or absent in hemolytic anemia. Normal adult findings range from 100 to 150 mg/dL. Compare transferrin. See also hemoglobinemia, hemoglobinuria.

haptoglobin

A protein in the circulation that migrates in the α2 portion of serum subjected to electrophoresis, a so-called acute phase reactant that ↑ in serum in acute inflammation or infection, stress, or necrosis Role Bind Hb released from RBCs undergoing hemolysis, preventing the accumulation of Hb in plasma; after iron has been removed, the haptoglobin-bound Hb is eliminated by the reticuloendothelial system.

hap·to·glo·bin

(hap'tō-glō'bin)
A group of α2-globulins in human serum, so called because of their ability to combine with hemoglobin; variant types form a polymorphic system, with α- and β-polypeptide chains controlled by separate genetic loci.
[G. haptō, to grasp, + hemoglobin]

haptoglobin

Alpha2 -globulin, a plasma protein that binds free haemoglobin to form a complex too large to pass out of the kidneys into the urine.

Haptoglobin

A blood protein made by the liver. Its main role is to save iron by attaching itself to any hemoglobin released from a red cell.

haptoglobin

a group of serum alpha2 globulin glycoproteins, produced by the liver, that bind free hemoglobin; important in acute phase reactions (response). The different types, genetically determined, are distinguished electrophoretically.
References in periodicals archive ?
NCBI_ID Name of proteins 1 1062 gi|296486435 TPA: vitamin D-binding protein precursor (Bos taurus) 2 630 gi|262050656 complement C4 precursor (Bos taurus) 3 1082 gi|86826758 Paraoxonase 1 (Bos taurus) 4 483 gi|157743038 A2M protein (Bos taurus) 5 616 gi|157743038 A2M protein (Bos taurus) 6 181 gi|28077107 endopin 1 (Bos taurus) 7 805 gi|28077107 endopin 1 (Bos taurus) 8 1083 gi|296480272 TPA: apolipoprotein A-IV precursor (Bos Taurus) 9 1131 gi|296480272 TPA: apolipoprotein A-IV precursor (Bos taurus) 10 1081 gi|42 alpha-1-antitrypsin (Bos taurus) 11 1087 gi|42 alpha-1-antitrypsin (Bos taurus) 12 1318 gi|83638561 Haptoglobin (Bos taurus) 13 1357 gi|83638561 Haptoglobin (Bos taurus) No.
Monocytes/macrophages were treated for 24,48,72 and 120 h with complexes of oleacein with haemoglobin and haptoglobin, or control.
Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.
Moreover significant difference have been encountered in acute phase response and results showed significant decrease in haptoglobin and fibrinogen in diseased newborns foals than in controls Table 3.
On the other hand, overall means of serum albumin, glucose and haptoglobin concentrations showed (PGreater than0.
For disease-free survival female gender, bulky disease and nodular sclerosis histological subtype were found to be negative prognostic factors, while early or advanced stage, age, ERS, B symptoms, anemia, leukocytosis, copper, fibrinogen, LDH level, ferritin and haptoglobin did not show an influence.
age, physical activity, MedDietScore, BMI, uric acid, creatinine, total cholesterol, HDL-cholesterol, LDL-cholesterol, cystatin C, haptoglobin, haemoglobin, haematocrit, white blood cells, monocytes, and platelets); as median (P25-P75) for the skewed ones (i.
Together with a markedly elevated lactate dehydrogenase (LDH) and reduced haptoglobin, this was consistent with haemolytic anaemia.
Haptoglobin was found to be lower during the first hour of hospitalization and increased during the next 36 hours.
She was diagnosed with as autoimmune hemolytic anemia (ATHA) based on a high reticulocyte count, positive direct Coombs test, hemoglobinuria, and low haptoglobin level, and received the conventional treatment of prednisone (2 mg/kg in divided doses) and blood transfusions.
a decreased haptoglobin level, unconjugated hyberbilirubinaemia, elevated serum lactate dehydrogenase and reticulocytosis.