hapten


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Related to hapten: complete antigen, Tolerogen

hapten

 [hap´ten]
a small molecule, not antigenic by itself, that can react with specific antibodies and elicit the formation of such antibodies when conjugated to a larger antigenic molecule, usually a protein, called in this context the carrier. Antibody production involves activation of B lymphocytes by the hapten and helper T cells by the carrier.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

hap·ten

(hap'-ten),
A molecule that is incapable, by itself, of causing a cell-mediated or humoral immune response but can, however, combine with a larger antigenic molecule called a carrier. A hapten-carrier complex can stimulate antibody production and reactive T-cells.
See also: hapten inhibition of precipitation.
[G. haptō, to fasten, bind]
Farlex Partner Medical Dictionary © Farlex 2012

hapten

(hăp′tĕn′) also

haptene

(-tēn′)
n.
A small molecule that reacts with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other large antigenic molecule.

hap·ten′ic adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

hap·ten

(hap'tĕn)
A molecule that is incapable, alone, of causing the production of antibodies but can, however, combine with a larger antigenic molecule called a carrier.
Synonym(s): incomplete antigen, partial antigen.
[G. haptō, to fasten, + -en, noun suffix]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

hapten

An incomplete antigen that cannot, by itself, promote antibody formation but that can do so when conjugated to a protein. Most haptens are organic substances of low molecular weight. From the Greek haptein , to fasten.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

hapten

a substance that is able to combine with specific antibodies but does not produce them unless attached to a large CARRIER MOLECULE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

hap·ten

(hap'tĕn)
A molecule that is incapable, alone, of causing the production of antibodies but can, however, combine with a larger antigenic molecule called a carrier.
Synonym(s): incomplete antigen, partial antigen.
[G. haptō, to fasten, + -en, noun suffix]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Subtoxic concentrations of allergenic haptens induce LC migration and maturation in a human organotypic skin explant culture model: a novel method for identifying potential contact allergens.
The name adjuvants, one of the conjugates used to increase the immunity of the haptens, is derived from the Latin word adjuvare, which means help or healing (12).
Currently, the T cell assay has been used to characterize the T cell response to a variety of drugs and drug haptens.
David, "Monoclonal antibody hapten radiopharmaceutical delivery," Nuclear Medicine Communications, vol.
Synthesis of BaP Hapten. BaP molecule does not contain functional groups that can connect with proteins.
Mice were immunized intraperitoneally with T cell-independent antigen TNP-Ficoll, a 2,4,6-trinitrophenyl hapten conjugated with Ficoll (25 [micro]g per mice), solved in PBS.
Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency.
Heparin-induced thrombocytopenia (HIT) is a prothrombotic disorder where heparin, a polyanion molecule, acts as a hapten when associated with PF4 causing IgG-mediated platelet activation.
Since the introduction of Nc/Nga mice as a spontaneously occurring model of AD, several other AD mouse models induced by skin injury and epicutaneous sensitization with allergens, such as ovalbumin, house dust mites, or hapten, have been developed over the past two decades [22, 23].
Bardies et al., "Two-step targeting of xenografted colon carcinoma using a bispecific antibody and [sup.188]Re-labeled bivalent hapten: Bio distribution and dosimetry studies," Journal of Nuclear Medicine, vol.
Bodet-Milin et al., "Targeting, toxicity, and efficacy of 2-step, pretargeted radioimmunotherapy using a chimeric bispecific antibody and 131I-labeled bivalent hapten in a phase I optimization clinical trial," Journal of Nuclear Medicine, vol.