Thirty-seven patients were able to complete the full study protocol, 2 had severe mucositis and hand-foot syndrome
while one patient died after septicaemia.
Of particular note, no patients developed hand-foot syndrome
, a common and debilitating side effect of fluoropyrimidine treatment.
Toxicities associated with clinical benefit from EGFR inhibitors include rash, xerosis, leukocytoclastic vasculitis, paronychia, and pruritus, whereas skin toxicities associated with the multikinase inhibitors trended toward the hand-foot syndrome
and hand-foot skin reaction.
 Pancreatic, 100 PR: 70 18 Grade 3-4 toxicity, SD: 27 12 Hand-foot syndrome
PD: 3 Ramirez et al.
Diffuse hyperpigmentation, Xerosis and Hand-foot syndrome
, developed in 4 patients each.
The most common adverse reactions (>20%) were diarrhea, painful palms and soles (palmar-plantar erythrodysaesthesia (PPE); also known as Hand-Foot Syndrome
), hypertension, and fatigue.
Multikinase inhibitors, a common cause of hand-foot syndrome
(HFS), are also associated with facial erythema, subungual splinter hemorrhages, and other skin changes, he added.
A history of hand-foot syndrome
and the number of transfusions of more than 3 per patient were associated with an increased risk of short stature with OR, respectively, 4.3 and 4.8.
This side effect is known variously as hand-foot syndrome
, palmar-plantar erythrodysesthesia (PPE) or hand-to-foot syndrome.
The most common grade 3/4 cediranib related toxicities on the original study were hypertension (36%), fatigue (30%), hand-foot syndrome
(16%), and diarrhea (11%).
(3) TEC includes Burgdorf's Reaction, erythrodysesthesia, acral erythema, toxic acral erythema, eccrine squamous syringometaplasia, epidermal dysmaturation, epidermal dystrophy, hand-foot syndrome
, palmar-plantar erythema, palmarplantar dysesthesia, and neutrophilic eccrine hidradenitis.
- Chemotherapy Induced Acral Erythema (Hand-Foot Syndrome
) Global Clinical Trials Review, H1, 2014