The acute hyponatremia was initially attributed to the continuous infusion of 5% dextrose half-normal saline
in association with presumed lung cancer induced SIADH.
Normal saline was used most often (80% of cases), followed by half-normal saline
(12%), and the median administered volume was 1,000 mL.
Prehydration with intravenous half-normal saline
was compared with prehydration with normal saline in a large, randomized trial, and the results favored normal saline for CIN prophylaxis.
With dextrose on board, a switch to half-normal saline