hairy-cell leukemia


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hairy-cell leukemia

Etymology: AS, haer + L, cella, storeroom; Gk, leukos, white, haima, blood
an uncommon neoplasm of blood-forming tissues, characterized by pancytopenia, enlargement of the spleen, and many fine projections on the surface of reticulum cells in the blood and bone marrow. The disease occurs six times more frequently in men than in women and usually appears in the fifth decade with an insidious onset and a variable course marked by anemia, thrombocytopenia, and spontaneous bruising. Some cases may achieve long-term remission through alpha-interferon administration or chemotherapy using vincristine and prednisone. Also called leukemic reticuloendotheliosis.
References in periodicals archive ?
People with hairy-cell leukemia have the opposite problem: abnormal proliferation of white cells.
In theory, at least, those compounds might target the errant lymphocytes causing hairy-cell leukemia.
This suggested that cladribine homed in on lymphocytes, and it paved the way for testing the drug in people with hairy-cell leukemia.
Such reports convinced the Food and Drug Administration last year to approve cladribine for the treatment of hairy-cell leukemia.
High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias.
GENENTECH BIOONCOLOGY PIPELINE Product Use/Potential Use Molecule Type Status Roferon-A Hairy-cell leukemia Biological Cleared (Interferon- AIDS-related Kaposi's response for alfa-2a, sarcoma modifier marketing recombinant) Philadelphia Chromosome Positive chronic myelogenous leukemia C2B8 antibody, Relapsed low grade Monoclonal BLA rituximab or follicular non- antibody Submitted Hodgkin's lymphoma March 1997 HER-2 antibody Metastatic breast Monoclonal Phase III cancer in patients antibody who overexpress HER2 protein TPO Blood platelet Blood cell Phase II stimulation growth factor VEGF antibody Various solid cancer Monoclonal Phase I tumors antibody