hairy cell leukaemia


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A low-grade B-cell leukaemia comprising 2% of adult leukaemia, commonly affecting men—male:female ratio, 4:1—age 50-55, leading to progressive pancytopenia; 10% have platelet counts of < 20 x 109/L—US: < 20,000/mm3—20% have thrombocytosis; 1-80% of nucleated RBCs are hairy.
The ‘classic’ or Japanese form—which comprises most cases of HCL—responds better to therapy than the non-classic or variant form
Lab Increased acid phosphatase, especially isoenzyme 5—increased in bone metastases and in Gaucher’s disease
Management First-line therapy: purine analogues 2’-deoxycoformycin (pentostatin) and 2-chlorodeoxyadenosine (cladribine)
Cause of death Infections, gram-negative bacteria, atypical mycobacteria, fungi

hairy cell leukaemia

A rare disease featuring overgrowth of B .LYMPHOCYTES usually in men between 40 and 60 years of age. The lymphocytes show prominent hair-like projections. There is a profound drop in the numbers of all blood cells and the spleen, which is the site of the bulk of the abnormal lymphocytes, is enlarged. Treatment is by spleen removal (splenectomy) and the use of drugs such as alpha-INTERFERON and deoxycoformycin.
References in periodicals archive ?
AstraZeneca, a UK-based pharmaceutical company, and MedImmune, its global biologics research and development arm, announced on Friday that the US Food and Drug Administration (FDA) has approved Lumoxiti (moxetumomab pasudotox-tdfk) for the treatment of adult patients with relapsed or refractory hairy cell leukaemia (HCL) who have received at least two prior systemic therapies, including treatment with a purine nucleoside analog.
The data regarding the influence of analogues of purine nucleosides on reproduction functions results undoubtedly from the epidemiology of hairy cell leukaemia (HCL).
Ferdie Stern passed away peacefully in Durban on 1 June 2010 in his 91st year, a victim of hairy cell leukaemia. His parents, Simon and Bertha, had emigrated from a small village, Rohatten, in Austria and settled in Dordrecht in the Eastern Cape where they farmed.
Jim was first diagnosed with the rare blood cancer, hairy cell leukaemia, in 2004.
Chronic Lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: report of three cases.
Innate is licensing the US and EU commercial rights to recently FDA-approved Lumoxiti (moxetumomab pasudotox) for hairy cell leukaemia (HCL).
M2 EQUITYBITES-September 17, 2018-AstraZeneca announces US FDA approval of Lumoxiti to treat hairy cell leukaemia
M2 PHARMA-September 17, 2018-AstraZeneca announces US FDA approval of Lumoxiti to treat hairy cell leukaemia
The differential diagnoses of PCL include B-cell chronic lymphocytic leukaemia, hairy cell leukaemia and marginal zone lymphomas with circulating lymphocytes.
Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1).
Around 21,500 people get leukaemia in the UK every year but fewer than 100 get the hairy cell leukaemia which attacked his body.